74347-50-5Relevant academic research and scientific papers
Synthesis and anti-cancer activity of naturally occurring 2,5-diketopiperazines
Mollica, Adriano,Costante, Roberto,Fiorito, Serena,Genovese, Salvatore,Stefanucci, Azzurra,Mathieu, Veronique,Kiss, Robert,Epifano, Francesco
, p. 91 - 97 (2014/08/18)
Three naturally occurring oxyprenylated diketopiperazines were synthesized and preliminarily tested as growth inhibitory agents in vitro against various cancer cell lines. The compounds were tested on six human cancer cell lines with different sensitivity to proapoptotic stimuli using the MTT colorimetric assay. The data revealed that of the chemicals under study only deoxymicelianamide (11) displayed the highest activity, recording mean IC50 growth inhibitory values ranging from 2 to 23 μM. A comparative study with the non-geranylated saturated derivative of (11) revealed the importance of the presence of the geranyloxy side chain and the exocyclic 2,5-DPK double bond moiety for the observed activity.
Structure and Synthesis of Phomamide, a New Piperazine-2,5-dione related to the Sirodesmins, isolated from the Culture Medium of Phoma lingam Tode
Ferezou, Jean-Pierre,Quesneau-Thierry, Annik,Barbier, Michel,Kollmann, Albert,Bousquet, Jean-Francois
, p. 113 - 115 (2007/10/02)
Several active substances are produced by the fungus Phoma lingam Tode, among which are the previously reported sirodesmins PL (1) and (2), sulphur-containing piperazinediones.A new metabolite, phomamide, also a piperazine-2,5-dione, has now been isolated
