74352-09-3

Upstream product

• 74352-13-9 (6E,8E)-1,1-Dimethoxy-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-6,8-dien-4-yn-3-ol 
• 74352-12-8 9-(2-propynyl)-β-ionyl acetate 
• 58508-29-5 trans-11,12-dideuteroretinol 
• 1430344-90-3 (2E,4E)-5-(benzyldimethylsilyl)-4,5-dideutero-3-methylpenta-2,4-dien-1-ol 
• 1430344-93-6 (E)-3-methylpent-2-en-4-yn-1-ol 
• 1430344-94-7 (E)-2-[(5-deutero-3-methylpent-2-en-4-yn-1-yl)oxy]tetrahydro-2H-pyran 
• 74352-11-7 6-(2-methyl-6,6-dimethylcyclohex-1-en-1-yl)-3-methylhex-1-ene-5-yne-3-ol 
• 79-77-6 (E)-β-ionone 
• 103633-89-2 3-(β-ionilidene)-1-propyne 

Downstream Products

• 74352-09-3 C₂₀H₂₆⁽²⁾H₂O 
• 74410-14-3 11-cis-11,12-dideuteroretinal 
• 74430-64-1 11,12-dideuterio-13-cis-retinal 

Relevant academic research and scientific papers

Synthesis of 11-cis-retinoids by hydrosilylation-protodesilylation of an 11,12-didehydro precursor: Easy access to 11- and 12-mono- and 11,12-dideuteroretinoids

An expeditious, highly efficient approach to 11-cis-retinoids was achieved by semihydrogenation of a readily available 11-yne precursor through a hydrosilylation-protodesilylation protocol. The complete chemo-, regio-, and syn-stereoselectivity of the method also allowed direct access to 11- and 12-monodeutero-, and 11,12-dideutero-11-cis-retinoids. The analogous trans series was not accessible by this route, and was synthesized by means of Hiyama coupling. Copyright

10-Mono-, 11-mono-, 12-mono and 11,12-dideuteroretinal

The 11-mono and 12-mono- and 11,12-dideuteroretinal (in the all-trans, 9-cis, 11-cis and 13-cis form) with > 98percent chemical purity and > 95percent mono- and dideuterium incorporation were prepared using the same scheme for all three compounds.The all-