74375-34-1

Upstream product

• 118-48-9 isatoic anhydride 
• 555-16-8 4-nitrobenzaldehdye 
• 75-04-7 ethylamine 

Downstream Products

• 74375-42-1 3-ethyl-2-(4-nitro-phenyl)-3H-quinazolin-4-one 

Relevant academic research and scientific papers

Water-accelerated synthesis of novel bis-2,3-dihydroquinazolin-4(1H)-one derivatives

Bisdihydroquinazolinones were synthesized for the first time by a novel pseudo five-component condensation of isatoic anhydride, a primary amine, and a dialdehyde in water. Several solvents were examined for this reaction; however, in terms of reaction yield and time, water was found to be the optimum solvent. Georg Thieme Verlag Stuttgart.

One-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones by Fe3O4@SiO2-imid-PMAn nano-catalyst under ultrasonic irradiation and reflux conditions

Abstract: Fe3O4@SiO2-imid-PMAn efficiently catalyzes the condensation reaction of isatoic anhydride, aldehydes, and primary amines or ammonium salts to afford the corresponding 2,3-dihydroquinazolin-4(1H)-one derivatives under ultrasonic irradiation or reflux conditions. This method gives notable advantages such as operational simplicity, excellent yields, short reaction times, and absence of any tedious workup or purification. In addition, the excellent catalytic performance and the easy preparation, thermal stability, and separation of the catalyst make it a good heterogeneous system and a useful alternative to other heterogeneous catalysts. Also, the aforementioned nanocatalyst can be easily recovered by a magnetic field and reused for subsequent reactions for at least six times without noticeable deterioration in catalytic activity and reaction yield. Graphical abstract: [Figure not available: see fulltext.]

Br?nsted acidic ionic liquids catalyze the preparation of 2,3-dihydroquinazolin-4(1H)-one derivatives

A simple and facile method for the green synthesis of 2,3- dihydroquinazolin-4(1H)-one derivatives by direct three-component cyclo-condensation of isatoic anhydride, ammonium acetate (or primary amines), and arylaldehydes using different Br?nsted acidic ionic liquids, for example 2-pyrrolidonium hydrogensulfate ([hnmp][HSO4]), N-methyl-2-pyrrolidonium hydrogensulfate ([NMP][HSO4]), and N-methyl-2-pyrrolidonium dihydrogenphosphate ([NMP][H2PO 4]), as reusable catalysts under solvent-free conditions is described. In addition, reaction of anthranilamide and arylaldehydes for synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives was investigated.

Silica supported zinc (II) chloride (SiO2-ZnCl2) as an efficient catalyst for the eco-friendly synthesis of 2,3-dihydroquinazolin- 4(1 H)-ones

Silica supported zinc (II) chloride (SiO2-ZnCl2) as an efficient and non-toxic heterogeneous catalyst have been used for the simple and facile synthesis of 2,3-dihydroquinazolin-4(1H)-ones through the direct cyclo-condensation of anthranilamide and aldehydes or one-pot three-component cyclo-condensation of isatoic anhydride, ammonium acetate (or amines) and aldehydes under solvent-free conditions.

Efficient one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones from aromatic aldehydes and their one-pot oxidation to quinazolin-4(3H)-ones catalyzed by Bi(NO3)3·5H2O: Investigating the role of the catalyst

An efficient and novel synthesis of 2,3-disubstituted 2,3- dihydroquinazolin-4(1H)-ones via one-pot, three-component reaction of isatoic anhydride, primary amines and aromatic aldehydes catalyzed by Bi(NO 3)3·5H2O under so

One-pot synthesis of 2,3-disubstituted-2,3-dihydroquinazolin-4(1H)-ones using [Hmim][NO3]: An eco-friendly protocol

An efficient method for the synthesis of a series of 2,3-disubstituted-2,3- dihydroquinazolin-4(1H)-ones is described via one-pot condensation reaction of isatoic anhydride, aryl aldehydes, and primary amines using a Bronsted acidic ionic liquid, [Hmim][N

Eco-friendly and efficient synthesis of 2,3-dihydroquinazolin-4(1H)-ones

A simple and facile method for the synthesis of 2,3-dihydroquinazolin-4(1H) -ones through the direct cyclocondensation of one-pot three-component cyclocondensation of isatoic anhydride, ammonium acetate (or primary amines) and aldehydes; and anthranilamide and aldehydes using silica supported ferric chloride (SiO2-FeCl3) as catalyst under solvent-free conditions is described.

One-pot, three-component synthesis of 2,3-dihydroquinazolin-4(1H)-ones using p-Toluenesulfonic acid-paraformaldehyde copolymer as an efficient and reusable catalyst

p-Toluenesulfonic acid-paraformaldehyde copolymer (copolymer-PTSA) catalyzes the three-component, one-pot condensation reaction of isatoic anhydride, ammonium salts or aromaticand aliphatic amines, and aldehydes in refluxing ethanol. The catalyst is reusable and could be recycled for several runs without any decrease in its efficiency. Springer-Verlag 2010.

Ionic liquid promoted eco-friendly and efficient synthesis of 2,3-dihydroquinazolin-4(1H)-ones

2,3-Dihydroquinazolin-4(1H)-ones were efficiently synthesised by the reaction of isatoic anhydride, a primary amine or ammonium acetate, and different aromatic aldehydes in 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim]BF4) without using any acidic catalyst. Also a bis-derivative of the title compound as a polyheterocyclic system was synthesised successfully in high yield.

One-pot, three-component synthesis of 2,3-dihydro-4(1H)-quinazolinones by montmorillonite K-10 as an efficient and reusable catalyst

A wide range of mono- and disubstituted dihydroquinazolinones were synthesised via condensation of isatoic anhydride, primary amines, or ammonium salts with aromatic aldehydes in the presence of montmorillonite K-10. The catalyst is reusable and could be recycled for several runs without any decrease in its efficiency. Copyright Taylor & Francis Group, LLC.