74375-41-0Relevant academic research and scientific papers
Rapid assembly of quinazolinone scaffold via copper-catalyzed tandem reaction of 2-bromobenzamides with aldehydes and aqueous ammonia: Application to the synthesis of the alkaloid tryptanthrin
Guo, Shenghai,Li, Yan,Tao, Li,Zhang, Wenwen,Fan, Xuesen
, p. 59289 - 59296 (2015/02/19)
An efficient and practical procedure for the preparation of 2-substituted and 2,3-disubstituted quinazolinones was achieved through copper-catalyzed tandem reaction of 2-bromobenzamides with aldehydes and aqueous ammonia under air. Control experimental results indicated that this tandem reaction is triggered by a copper-catalyzed direct amination of 2-bromobenzamides with aqueous ammonia, followed by cyclocondensation and oxidative aromatization. As an application, this novel methodology provides a concise and practical one-pot route to the synthesis of alkaloid tryptanthrin. This journal is
Synthesis of quinazolinones from alcohols via laccase-mediated tandem oxidation
Heidary, Marjan,Khoobi, Mehdi,Ghasemi, Sabrieh,Habibi, Zohreh,Faramarzi, Mohammad Ali
, p. 1789 - 1794 (2014/06/09)
This paper describes the synthesis of quinazolinones via a tandem reaction using the laccase-mediator system under mild conditions. The procedure involved the laccase-catalyzed oxidation of alcohols to the corresponding aldehydes, followed by cyclocondensation with isatoic anhydride and a number of amines to afford 2,3-dihydroquinazolin-4(1H)-ones, which were further oxidized to quinazolinones in useful yields. The use of an enzyme as the catalyst, O 2 as an environmentally friendly oxidant, and a citrate buffer as the green solvent represents a novel and efficient approach for the one-pot synthesis of quinazolinones.
Efficient one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones from aromatic aldehydes and their one-pot oxidation to quinazolin-4(3H)-ones catalyzed by Bi(NO3)3·5H2O: Investigating the role of the catalyst
Mohammadpoor-Baltork, Iraj,Khosropour, Ahmad R.,Moghadam, Majid,Tangestaninejad, Shahram,Mirkhani, Valiollah,Baghersad, Saeid,Mirjafari, Arsalan
experimental part, p. 944 - 952 (2012/04/23)
An efficient and novel synthesis of 2,3-disubstituted 2,3- dihydroquinazolin-4(1H)-ones via one-pot, three-component reaction of isatoic anhydride, primary amines and aromatic aldehydes catalyzed by Bi(NO 3)3·5H2O under so
