74375-43-2

Basic information

• Product Name: 3-ethyl-2-(3-nitro-phenyl)-3H-quinazolin-4-one
• Synonyms: 3-ethyl-2-(3-nitro-phenyl)-3H-quinazolin-4-one
• CAS NO: 74375-43-2
• Molecular Weight: 295.298
• Mol File: 74375-43-2.mol

Chemical Properties

• CAS DataBase Reference: 3-ethyl-2-(3-nitro-phenyl)-3H-quinazolin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ethyl-2-(3-nitro-phenyl)-3H-quinazolin-4-one(74375-43-2)
• EPA Substance Registry System: 3-ethyl-2-(3-nitro-phenyl)-3H-quinazolin-4-one(74375-43-2)

Safety Data

• Hazardous Substances Data: 74375-43-2(Hazardous Substances Data)

Upstream product

• 118-48-9 isatoic anhydride 
• 99-61-6 3-nitro-benzaldehyde 
• 75-04-7 ethylamine 
• 74375-35-2 3-ethyl-2-(3-nitrophenyl)-2,3-dihydroquinazolin-4(1H)-one 

Relevant articles and documents

Synthesis of quinazolinones from alcohols via laccase-mediated tandem oxidation

This paper describes the synthesis of quinazolinones via a tandem reaction using the laccase-mediator system under mild conditions. The procedure involved the laccase-catalyzed oxidation of alcohols to the corresponding aldehydes, followed by cyclocondensation with isatoic anhydride and a number of amines to afford 2,3-dihydroquinazolin-4(1H)-ones, which were further oxidized to quinazolinones in useful yields. The use of an enzyme as the catalyst, O 2 as an environmentally friendly oxidant, and a citrate buffer as the green solvent represents a novel and efficient approach for the one-pot synthesis of quinazolinones.