74385-25-4Relevant academic research and scientific papers
SYNTHESIS OF A CARBOCYCLIC ANALOG OF QUERCETIN VIA A BARBIER REACTION
Shih, Neng-Yang,Mangiaracina, Pietro,Green, Michael J.,Ganguly, Ashit K.
, p. 5563 - 5566 (2007/10/02)
A six-step synthetic route to the carbocyclic flavonoid 2 is described.The key step involves a 1,4-addition of a tertiary bromide to a α,β-unsaturated ester by the Barbier reaction.
Antiestrogens. Synthesis and Evaluation of Mammary Tumor Inhibiting Activity of 1,1,2,2-Tetraalkyl-1,2-diphenylethanes
Hartmann, Rolf W.,Kranzfelder, Gerhard,Angerer, Erwin, v.,Schoenenberger, Helmut
, p. 841 - 848 (2007/10/02)
Among the newly synthesized 1,1,2,2-tetraalkyl-1,2-diphenylethanes, 1,1,2,2-tetramethyl-1,2-bis(4'-hydroxyphenyl)ethane (23) and 1,1,2,2-tetramethyl-1,2-bis(3'-hydroxyphenyl)ethane (26) were the most active compounds regarding estradiol receptor affinity, exhibiting Ka values of 0.73*108 and 0.67*108 M-1, respectively.In vivo, 23 and 26 showed only very small uterotrophic activity in the mouse.They strongly inhibited (73percent) the estrone-stimulated mouse uterine growth.Tested on the 9,10-dimethyl-1,2-benzanthracene induced hormone-dependent mammary adenocarcinoma of the Sprague-Dawley rat, compounds 23 and 26 exhibited a dose-dependent inhibition of the tumor growth, having a strong effect at a dose of 20 (mg/kg)/day (compound 23).
