74386-98-4Relevant academic research and scientific papers
Pharmacokinetics of hypolipidemic agents, X: Second contribution to the problem of the dehalogenation of the lipid lowering agent ciprofibrate
Oelschlager,Hellwich,Rothley
, p. 261 - 265 (1994)
rac-2 described as a metabolite of rac-1 was synthesized in four steps starting with rac-3. Partial dehalogenation occurs with LiAlH4. A new structure assignment of the resulting stereoisomers resulted from NMR spectroscopy. After oral administration of rac-1 in multiple dose studies to volunteers, rac-2 could not be detected within the limitations of sensitivity of HPLC (UV-detector) in plasma or in urine.
EFFECT OF THE NATURE OF SUBSTITUENTS IN THE THREE-CARBON RING ON THE DEMETHYLATION OF p-CYCLOPROPYLANISOLES DURING NITRATION
Mochalov, S. S.,Karpova, V. V.,Shabarov, Yu. S.
, p. 495 - 503 (2007/10/02)
The behavior of a series of p-cyclopropylanisoles substituted in the small ring was investigated under conditions favoring their demethylation during nitration.It was shown that the yields of the nitrophenols which form depend on the nature and on the pos
