Pharmacokinetics of hypolipidemic agents, X: Second contribution to the problem of the dehalogenation of the lipid lowering agent ciprofibrate

Article abstract of DOI:10.1002/ardp.19943270412

rac-2 described as a metabolite of rac-1 was synthesized in four steps starting with rac-3. Partial dehalogenation occurs with LiAlH₄. A new structure assignment of the resulting stereoisomers resulted from NMR spectroscopy. After oral administration of rac-1 in multiple dose studies to volunteers, rac-2 could not be detected within the limitations of sensitivity of HPLC (UV-detector) in plasma or in urine.