Archiv der Pharmazie p. 261 - 265 (1994)
Update date:2022-08-05
Topics:
Oelschlager
Hellwich
Rothley
rac-2 described as a metabolite of rac-1 was synthesized in four steps starting with rac-3. Partial dehalogenation occurs with LiAlH4. A new structure assignment of the resulting stereoisomers resulted from NMR spectroscopy. After oral administration of rac-1 in multiple dose studies to volunteers, rac-2 could not be detected within the limitations of sensitivity of HPLC (UV-detector) in plasma or in urine.
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Doi:10.1039/P29800000890
(1980)Doi:10.1021/jo01309a013
(1980)Doi:10.1002/cctc.201900382
(2019)Doi:10.1016/S0008-6215(00)90739-0
(1985)Doi:10.1002/anie.201004779
(2011)Doi:10.1021/ja01204a007
(1947)
