74389-78-9

Basic information

• Product Name: 3-Buten-2-one, 4-[4-(1-Methylethyl)phenyl]-
• Synonyms: 3-Buten-2-one, 4-[4-(1-Methylethyl)phenyl]-
• CAS NO: 74389-78-9
• Molecular Formula: C₁₃H₁₆O
• Molecular Weight: 188.26554
• Mol File: 74389-78-9.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Buten-2-one, 4-[4-(1-Methylethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Buten-2-one, 4-[4-(1-Methylethyl)phenyl]-(74389-78-9)
• EPA Substance Registry System: 3-Buten-2-one, 4-[4-(1-Methylethyl)phenyl]-(74389-78-9)

Safety Data

• Hazardous Substances Data: 74389-78-9(Hazardous Substances Data)

Upstream product

• 67-64-1 acetone 
• 122-03-2 (4-isopropylbenzaldehyde) 

Downstream Products

• 81467-67-6 N'-[(E)-3-(4-Isopropyl-phenyl)-1-methyl-prop-2-en-(E)-ylidene]-N,N-dimethyl-hydrazine 
• 111991-42-5 4-[5-(4'-isopropylphenyl)-3-oxo-1,4-pentadienyl]benzoic acid methyl ester 
• 10528-64-0 4-(4-isopropyl-phenyl)-butan-2-one 
• 3368-21-6 (E)-4-isopropylcinnamic acid 

Relevant articles and documents

Chiral δ-iodo-γ-lactones derived from cuminaldehyde, 2,5-dimethylbenzaldehyde and piperonal: Chemoenzymatic synthesis and antiproliferative activity

Six enantiomeric pairs of β-aryl-δ-iodo-γ-lactones 8a-c, 9a-c derived from cuminaldehyde, 2,5-dimethylbenzaldehyde and piperonal were synthesized with high enantiomeric purities (ee 93-99%) from enantiomerically enriched allyl alcohols 3a-c. The key step

Synthesis and neuroprotective evaluation of (E)-3,4-dihydroxystyryl p-substituted-phenethyl ketone derivatives against inflammatory and oxidative injury

(E)-3,4-dihydroxystyryl p-substituted-phenethyl ketones and their 3,4-diacetylated derivatives were synthesized and examined their neuroprotective activities to further study the effect of p-substituents on the aromatic ring. The results revealed that steric hindrance effect of p-substituents has impact on neuroprotective activities against inflammatory and oxidative injury. Introduction of the bulkier groups are more beneficial to improve the neuroprotective activities than smaller groups. Compounds (4–5h, 4–5i and 4–5e) with p-substituted trifluoromethyl, isopropyl and t-butyl groups exhibited the best effects among all the target compounds.

Synthesis and anticancer activity of novel halolactones with β-aryl substituents from simple aromatic aldehydes

A series of 20 novel racemic iodo-, bromo- and chlorolactones, possessing β-phenyl-γ-lactone or β-phenyl-δ-lactone framework, were synthesized from commercially available aromatic aldehydes in convenient five-step syntheses. Some of them showed noticeable cytotoxic effect against two cancer lines, Jurkat (human leukaemia) and D17 (canine osteosarcoma). The highest activity, comparable with carboplatin, was observed for cis-5-(1-iodoethyl)-4-(4′-isopropylphenyl)dihydrofuran-2-one against Jurkat cell line.