74395-18-9

Usage

Uses

Used in Pharmaceutical Industry:
4-Methylthiophene-2-ylmethanol is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of novel therapeutic agents. Its unique chemical structure allows for the creation of functionalized thiophene derivatives, which can be incorporated into drug molecules to enhance their efficacy and properties.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Methylthiophene-2-ylmethanol is utilized as a starting material for the production of agrochemicals. Its role in the synthesis of various chemical compounds enables the development of innovative products that can improve crop protection and yield.
Used in Fragrance Industry:
4-Methylthiophene-2-ylmethanol is employed as a component in the creation of fragrance ingredients due to its slightly fruity odor. Its incorporation into fragrances adds unique and desirable scent profiles to various consumer products, such as perfumes, cosmetics, and personal care items.
Used as a Chemical Intermediate:
4-Methylthiophene-2-ylmethanol is commonly used as an intermediate in the production of various chemicals. Its versatility as a starting material allows for the preparation of a wide range of functionalized thiophene derivatives, which can be further utilized in different chemical processes and applications.
It is crucial to handle 4-Methylthiophene-2-ylmethanol with care, as it may pose health risks if ingested, inhaled, or comes into contact with the skin. Proper safety measures should be taken during its use and storage to ensure the well-being of individuals and the environment.

InChI:InChI=1/C6H8OS/c1-5-2-6(3-7)8-4-5/h2,4,7H,3H2,1H3

Upstream product

• 50-00-0 formaldehyd 
• 616-44-4 3-Methylthiophene 
• 6030-36-0 4-methylthiophene-2-carbaldehyde 
• 14282-78-1 4-methylthiophene-2-carboxylic acid 
• 28686-90-0 4-methyl-thiophene-2-carboxylic acid methyl ester 

Downstream Products

• 1085941-51-0 (R)-2-(1-amino-2-methylpropyl)-8-fluoro-3-((4-methylthiophen-2-yl)methyl)benzofuro[3,2-d]pyrimidin-4(3H)-one 
• 1309207-77-9 1-benzhydryl-3-(4-methylthiophen-2-ylmethoxy)azetidine 
• 913828-93-0 {4-methyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl }methanol 
• 1028947-16-1 C₂₆H₃₀N₂O₃SSi 

Relevant academic research and scientific papers

MUSCARINIC AGONISTS AS NON-STEROIDAL AND NON-OPIOID ANALGESICS AND METHODS OF USE THEREOF

Novel Gi/o-biased muscarinic agonists selectively activate only one specific signaling pathway and are novel pharmacophores for development of new painkillers (analgesics). Methods of making and using these agonists are also described.

SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS AS RXR AGONISTS

The present invention relates to certain substituted bicyclic compounds that are agonists of RXR and which are therefore useful in the treatment of certain disorders that can be prevented or treated by activation of this receptor. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders.

Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist

S1P3-sparing S1P1 agonists have attracted attention as a suppressant of autoimmunity with reduced side effects. Our synthetic efforts and extensive SAR studies led to the discovery of 10b named CS-2100 with the EC50 value of 4.0 nM for human S1P1 and over 5000-fold selectivity against S1P3. The in vivo immunosuppressive efficacy was evaluated in rats on host versus graft reaction and the ID 50 value was determined at 0.407 mg/kg. The docking studies of CS-2100 with the homology model of S1P1 and S1P3 showed that the ethyl group on the thiophene ring of CS-2100 was sterically hindered by Phe263 in S1P3, not in the case of Leu276 in S1P1. This observation gives an explanation for the excellent S1P3-sparing characteristic of CS-2100.

NOVEL HETEROCYCLIC ACRYLAMIDES AND THEIR USE AS PHARMACEUTICALS

The invention relates to novel heterocyclic acrylamide compounds (I), to the preparation of the compounds and intermediates used therein, to the use of the compounds as antibacterial medicaments and pharmaceutical compositions containing the compounds.

Practical access to metallo thiophenes: Regioselective synthesis of 2,4-disubstituted thiophenes

This report describes a protocol for functionalization of thiophenes, utilizing a regioselective magnesiation mediated by commercial Grignard reagents and catalytic 2,2,6,6-tetramethylpiperidine. This metalation provides practical access to metallo thiophenes, avoiding cryogenic conditions, prolonged reaction times, and prohibitively expensive reagents. Application to a target thiophene-phthalazinone 6 was accomplished by addition of 2-magnesio-4- methylthiophene to phthalic anhydride, providing the product with >40:1 regioselectivity. This also solved a chemoselectivity issue encountered with analogous lithio-thiophene reagents and cyclic anhydrides, or with magnesio-thiophene generated by simultaneous lithium-to-magnesium transmetalation/anhydride acylation. These alternative in situ transmetalation sequences were plagued by an age effect dictated by the kinetic solubility of MgCl2/THF complexes.

Synthesis of Benzophenalenothiophene and Benzophenalenothiophene

Two pentacyclic thiophenes, benzophenalenothiophene (1) and benzophenalenothiophene (2) were synthesized via the corresponding 3-methylphenanthrothiophene (7) and 1-methylanthrathiphene (19).