74396-53-5

Usage

Uses

Used in Organic Synthesis:
2-(Propylamino)benzonitrile is utilized as a building block in organic synthesis, contributing to the creation of a wide range of chemical compounds. Its unique structure allows for various chemical reactions, facilitating the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 2-(Propylamino)benzonitrile serves as a key intermediate for the development of various pharmaceuticals. Its incorporation into drug molecules can enhance their therapeutic properties, making it an essential component in medicinal chemistry.
Used in Agrochemical Industry:
2-(Propylamino)benzonitrile also finds application in the agrochemical industry, where it is used as a precursor for the synthesis of agrochemicals. Its reactivity and structural features enable the production of effective compounds for agricultural use.
Used as a Precursor for Dyes and Pigments:
Furthermore, 2-(Propylamino)benzonitrile is employed as a precursor in the synthesis of dyes and pigments. Its chemical properties allow for the development of a diverse array of colorants used in various industries, such as textiles, plastics, and inks.

Upstream product

• 106-94-5 propyl bromide 
• 1885-29-6 anthranilic acid nitrile 
• 107-08-4 1-iodo-propane 
• 615-36-1 2-bromoaniline 
• 394-47-8 2-fluorobenzonitrile 
• 19788-34-2 N-nitroso-N-n-propylaniline 
• 55305-43-6 N-cyano-N-phenyl-p-toluenesulfonamide 
• 107-10-8 propylamine 
• 2042-37-7 o-cyanobromobenzene 

Downstream Products

• 74396-56-8 [2-(4,5-Dihydro-1H-imidazol-2-yl)-phenyl]-propyl-amine 

Relevant academic research and scientific papers

Substituted conformationally restricted guanidine derivatives: Probing the α2-adrenoceptors’ binding pocket

In this paper we report the design, synthesis and pharmacological evaluation of new N-substituted 2-amino-1,4-dihydroquinazolines, 2-amino-1,4-dihydropyridopyrimidines and 2-amino-4,5-dihydro-1,3-benzodiazepines as α2-adrenoceptors ligands. Computational studies show that the proposed substitutions and guanidine-containing ring size will probe an extensive area of the active site. Preparation of these molecules involved novel routes than those previously utilised in our laboratory for the preparation of the acyclic aryl-guanidine counterparts. Compounds 8b and 18c showed the highest affinity and antagonistic activity, within their series, towards the α2-adrenoceptor in human brain tissue in?vitro experiments. Structure-activity relationships have been established for the design and biological evaluation of novel α2-adrenoceptor ligands.

Rhodium(III)-Catalyzed Direct Cyanation of Aromatic C-H Bond to Form 2-(Alkylamino)benzonitriles Using N-Nitroso As Directing Group

2-(Alkylamino)benzonitriles were synthesized via a rhodium-catalyzed cyanation on the aryl C-H bond and subsequent denitrosation of N-nitrosoarylamines using a removable nitroso as the directing group, in which N-cyano-N-phenyl-p-methylbenzenesulfonamide (NCTS) was used as the "CN" source. Various substituents on the aryl ring and amino group of N-nitrosoarylamines tolerated the reaction, and the corresponding products were achieved in moderate to good yields.

4-Hydroxyquinol-2-ones. 86. Synthesis of methyl (ethyl) esters of 1-substituted 4-amino-2-oxoquinoline-3-carboxylic acids

Several variants of the synthesis of esters of 1-N-substituted 4-amino-2-oxoquinoline-3-carboxylic acids have been studied, one of which is recommended as preparative. 2005 Springer Science+Business Media, Inc.

Method of inhibiting neoplastic cells with imidazoquinazoline derivatives

A method for inhibiting neoplasia, particularly cancerous and precancerous lesions by exposing the affected cells to imidazoquinazoline derivatives.

Imidazoquinazoline derivatives

PCT No. PCT/JP97/03023 Sec. 371 Date Apr. 27, 1998 Sec. 102(e) Date Apr. 27, 1998 PCT Filed Aug. 29, 1997 PCT Pub. No. WO98/08848 PCT Pub. Date Mar. 5, 1998Imidazoquinoline derivatives of the formula (wherein X may be O or S) provide selective cyclic guanosine 3',5' monophosphate (cGMP)-specific phosphodiesterase (PDE) inhibitory activity. The compounds are useful for treating or ameliorating cardiovascular disease such as thrombosis, angina pectoris, hypertension, heart failure and arterial sclerosis, as well as asthma, impotence and the like.

Synthesis of 2-(alkylamino)benzonitriles from α-(bromoarylamino)nitriles

The treatment of α-(bromoarylamino)nitriles with Bu3SnH/AIBN induced 1,4-cyano group migration which led to 2-(alkylamino)benzonitriles.