74412-44-5

Usage

InChI:InChI=1/C23H38O5S/c1-3-4-7-10-18(25)13-14-20-19(21(26)17-22(20)29-16-15-24)11-8-5-6-9-12-23(27)28-2/h5,8,13-14,18-20,22,24-25H,3-4,6-7,9-12,15-17H2,1-2H3/b8-5-,14-13+/t18-,19+,20+,22+/m0/s1

Upstream product

• 31753-19-2 (5Z,13E)-15-hydroxy-9-oxoprosta 5,10,13 trien-1-oic acid 
• 60-24-2 2-hydroxyethanethiol 
• 67693-78-1 (Z)-7-<3-<(2-hydroxyethyl)thio>-5-oxo-1-cyclopenten-1-yl>-5-heptenoic acid methyl ester 
• 67693-79-2 (Z)-7-<5-oxo-3-<<2-<(trimethylsilyl)oxy>ethyl>thio>-1-cyclopenten-1-yl>-5-heptenoic acid methyl ester 

Relevant academic research and scientific papers

Prostaglandins and congeners. XXII. Synthesis of 11-substituted derivatives of 11-de-oxyprostaglandins E1 and E2. Potential bronchodilators

The interesting bronchodilator activity of l-11-deoxy-11α-[(2-hydroxyethyl)thiolprostaglandin E2 methyl ester (3a) is described. The preparation of 3a and its analogues by Michael-type additions to various members of the PGA series or by total synthesis using the lithiocuprate conjugate addition process is also described. Structure-activity relationships in this series are discussed.