Journal of Medicinal Chemistry p. 903 - 913 (1980)
Update date:2022-08-03
Topics:
Floyd
Schaub
Siuta
et al.
The interesting bronchodilator activity of l-11-deoxy-11α-[(2-hydroxyethyl)thiolprostaglandin E2 methyl ester (3a) is described. The preparation of 3a and its analogues by Michael-type additions to various members of the PGA series or by total synthesis using the lithiocuprate conjugate addition process is also described. Structure-activity relationships in this series are discussed.
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Doi:10.1021/jm00183a004
(1980)Doi:10.1007/BF00765253
(1983)Doi:10.1081/SCC-120002710
(2002)Doi:10.1002/pen.10032
(1903)Doi:10.1080/10426500490459731
(2004)Doi:10.1021/ja047200l
(2004)
