74413-96-0

Upstream product

• 804437-23-8 (3-methyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-ylmethylene)-malononitrile 
• 947-95-5 5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole 
• 109-77-3 malononitrile 
• 4942-70-5 4-(dimethylaminomethylene)-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one 

Downstream Products

• 74413-98-2 5-Carboxamido-3-methyl-6-oxo-1-phenyl-2H-pyrano<2,3-c>pyrazol 
• 1206477-57-7 2-amino-4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-5-oxo-1-phenyl-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1206477-59-9 C₂₇H₂₄ClN₅O 
• 1206477-63-5 C₂₆H₂₁Cl₂N₅O 
• 1206477-61-3 C₂₇H₂₄ClN₅O₂ 
• 1206477-67-9 2-amino-4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-1-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 1206477-65-7 C₂₆H₂₁BrClN₅O 
• 74414-00-9 5-ethoxycarbonyl-3-methyl-1-phenyl-6-oxo-1(6H)-pyrano<2,3-c>pyrazole 

Relevant academic research and scientific papers

P2O5/SiO2 as an efficient heterogeneous catalyst for the synthesis of heterocyclic alkene derivatives under thermal solvent-free conditions

A highly efficient methodology is developed for the synthesis of a series of heterocyclic alkene derivatives 3a-k from 5-chloro-3-methyl-1-phenylpyrazole- 4-carboxaldehyde 1 and active methylene compounds 2a-k, in the presence of P2O5/sub

New Routes for Novel Pyrazolo[3,4-b][1,6]-naphthyridine, Pyrazolo[3,4-b]pyridine and Pyrazolo[3,4:2,3]pyrido[6,1-a]benzimidazole Derivatives

Pyrazolo[3,4-b][1,6]naphthyridine, pyrazolo[3,4-b]pyridine and pyrazolo[3.4:2,3]pyrido[6,1-a]benzimidazole derivatives have been synthesized starting from the 5-chloro-3-substituted-1-phenylpyrazole-4-carboxaldehyde.

Novel reactions of 5-chloro-4-formyl-3-methyl-1-phenylpyrazole with active methylene compounds

Condensation of 5-chloro-4-formyl-3-methyl-1-phenylpyrazole (1) with malononitrile in the presence of piperidine or ammonium acetate affords the corresponding pyrazole derivatives (2-4). Base-catalyzed cyclocondensation of 1 with hippuric acid or ethyl glycinate hydrochloride gives the oxazolone 6 and 5-amino-3-methyl-6-oxo-1-phenyl-1,6-dihydropyrano[2,3-c]pyrazole (7) respectively. Treatment of 1 with ethyl cyanoacetate in basic medium produce ethyl α-cyano-β-(5-chloro-3-methyl-1-phenylpyrazol-4-yl)acrylate (8) which reacts with nitrogen nucleophiles to give compounds 9-12. Transesterification and/or hydrolysis of ester group has been observed on treatment of 8 with methyl alcohol in basic medium leading to the formation of acrylate derivatives (13-15). Compound 8 on treatment with ethyl acetoacetate or cyclohexanone undergoes condensation with subsequent cyclization and/or dearylation to give the adducts 16 and 17 respectively. Structures of all the products have been established by elemental analysis, IR, PMR and mass spectral data.