744208-68-2

Upstream product

• 744208-90-0 C₃₀H₅₂O₈ 
• 744208-89-7 (S)-di-tert-butyl 2-hydroxy-2-((R)-1-hydroxy-11-oxooctadec-3-en-2-yl)succinate 
• 744208-88-6 (4S,5S)-tert-butyl 4-(2-(tert-butoxy)-2-oxoethyl)-5-(8-(2-heptyl-1,3-dioxolan-2-yl)oct-1-en-1-yl)-2,2-dimethyl-1,3-dioxane-4-carboxylate 
• 744208-87-5 2-((4S,5S)-5-(8-(2-heptyl-1,3-dioxolan-2-yl)oct-1-en-1-yl)-4-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethanol 
• 744208-86-4 C₅₉H₈₆O₆Si₂ 
• 744208-85-3 C₅₆H₈₂O₆Si₂ 
• 744208-84-2 ((2S,3R)-3-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-3-(((tert-butyldiphenylsilyl)oxy)methyl)oxiran-2-yl)methanol 
• 1378532-02-5 tert-butyl(((2R,3S)-2-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-3-(((4-methoxybenzyl)oxy)methyl)oxiran-2-yl)methoxy)diphenylsilane 
• 1378532-01-4 (2S,3S)-5-((tert-butyldiphenylsilyl)oxy)-3-(((tert-butyldiphenylsilyl)oxy)methyl)-1-((4-methoxybenzyl)oxy)-3-(methylthio)pentan-2-ol 
• 1378532-00-3 (3S,4S)-3-(hydroxymethyl)-5-((4-methoxybenzyl)oxy)-3-(methylthio)pentane-1,4-diol 

Relevant academic research and scientific papers

A direct catalytic asymmetric aldol reaction of α-sulfanyl lactones: Efficient synthesis of SPT inhibitors

Softly does it: The title reaction, catalyzed by a AgPF6/(R)- biphep-type ligand/DBU complex, is described (see scheme). This protocol gives efficient access to syn-configured α-sulfanyl-β-hydroxy lactones in a highly enantioselective manner. In one particular case, the sulfide group was stereospecifically replaced with a hydroxy group to afford an enantioenriched tertiary alcohol, which upon further manipulation led to a class of densely functionalized SPT inhibitors. Copyright