744208-85-3

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 744208-96-6 2-heptyl-2-(oct-7-yn-1-yl)-1,3-dioxolane 
• 744208-84-2 ((2S,3R)-3-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-3-(((tert-butyldiphenylsilyl)oxy)methyl)oxiran-2-yl)methanol 
• 1378532-02-5 tert-butyl(((2R,3S)-2-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-3-(((4-methoxybenzyl)oxy)methyl)oxiran-2-yl)methoxy)diphenylsilane 
• 1378532-01-4 (2S,3S)-5-((tert-butyldiphenylsilyl)oxy)-3-(((tert-butyldiphenylsilyl)oxy)methyl)-1-((4-methoxybenzyl)oxy)-3-(methylthio)pentan-2-ol 
• 1378532-00-3 (3S,4S)-3-(hydroxymethyl)-5-((4-methoxybenzyl)oxy)-3-(methylthio)pentane-1,4-diol 

Downstream Products

• 744208-86-4 C₅₉H₈₆O₆Si₂ 
• 744208-68-2 C₃₁H₄₅NO₁₀ 
• 744208-91-1 (S)-di-tert-butyl 2-((S,Z)-1-(((S)-3-(4-(but-2-yn-1-yloxy)phenyl)-1-(tert-butoxy)-1-oxopropan-2-yl)amino)-1,11-dioxooctadec-3-en-2-yl)-2-hydroxysuccinate 
• 744208-75-1 NA 808 

Relevant academic research and scientific papers

A direct catalytic asymmetric aldol reaction of α-sulfanyl lactones: Efficient synthesis of SPT inhibitors

Softly does it: The title reaction, catalyzed by a AgPF6/(R)- biphep-type ligand/DBU complex, is described (see scheme). This protocol gives efficient access to syn-configured α-sulfanyl-β-hydroxy lactones in a highly enantioselective manner. In one particular case, the sulfide group was stereospecifically replaced with a hydroxy group to afford an enantioenriched tertiary alcohol, which upon further manipulation led to a class of densely functionalized SPT inhibitors. Copyright