744219-32-7 Usage
Uses
Used in Pharmaceutical Research and Drug Development:
1-Boc-4-(3-Iodo-1H-indazol-4-yl)piperazine is used as a building block for the synthesis of various biologically active molecules, contributing to the development of new pharmaceutical agents. Its presence in the compound allows for the creation of diverse chemical entities with potential therapeutic applications.
Used in Medicinal Chemistry:
1-Boc-4-(3-Iodo-1H-indazol-4-yl)piperazine is used as a valuable tool in medicinal chemistry for the exploration of its structural features and their implications in the design of new drugs. 1-Boc-4-(3-Iodo-1H-indazol-4-yl)piperazine's properties can guide the optimization of drug candidates for improved efficacy and safety.
Used in Chemical Biology Studies:
In chemical biology, 1-Boc-4-(3-Iodo-1H-indazol-4-yl)piperazine is used to investigate its interactions with biological systems, providing insights into its potential pharmacological properties and mechanisms of action. This can lead to a better understanding of its role in biological processes and its application in therapeutic interventions.
Used in Drug Discovery:
1-Boc-4-(3-Iodo-1H-indazol-4-yl)piperazine is used as a subject of interest for further investigation and development in the field of drug discovery. Its unique structure and potential pharmacological properties make it a promising candidate for the identification of new therapeutic agents and the advancement of medical treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 744219-32-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,4,4,2,1 and 9 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 744219-32:
(8*7)+(7*4)+(6*4)+(5*2)+(4*1)+(3*9)+(2*3)+(1*2)=157
157 % 10 = 7
So 744219-32-7 is a valid CAS Registry Number.
InChI:InChI=1/C16H21IN4O2/c1-16(2,3)23-15(22)21-9-7-20(8-10-21)12-6-4-5-11-13(12)14(17)19-18-11/h4-6H,7-10H2,1-3H3,(H,18,19)
744219-32-7Relevant academic research and scientific papers
5-piperazinyl-3-sulfonylindazoles as potent and selective 5-hydroxytryptamine-6 antagonists
Liu, Kevin G.,Robichaud, Albert J.,Bernotas, Ronald C.,Yan, Yinfa,Lo, Jennifer R.,Zhang, Mei-Yi,Hughes, Zoe A.,Huselton, Christine,Zhang, Guo Ming,Zhang, Jean Y.,Kowal, Dianne M.,Smith, Deborah L.,Schechter, Lee E.,Comery, Thomas A.
scheme or table, p. 7639 - 7646 (2011/02/21)
As part of our efforts to develop agents for CNS diseases, we have been focused on the 5-HT6 receptor in order to identify potent and selective ligands for cognitive enhancement. Herein we report the identification of a novel series of 5-piperazinyl-3-sulfonylindazoles as potent and selective 5-HT6 antagonists. The synthesis, SAR, and pharmacokinetic and pharmacological activities of some of the compounds including 3-(naphthalen-1-ylsulfonyl)-5-(piperazin-1-yl)-1H-indazole (WAY-255315 or SAM-315) will be described.
Heterocyclyl-3-sulfonylindazoles as 5-hydroxytryptamine-6 ligands
-
Page/Page column 20, (2008/06/13)
The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of disorders related to or affected by the 5-HT6 receptor.
