1253422-84-2 Usage
Selective inhibitor of Aurora A kinase
MLN8054 is a chemical that specifically inhibits the activity of Aurora A kinase, a key regulator of cell division.
Anti-cancer potential
Aurora A kinase is overexpressed in many cancer types and is associated with poor prognosis, making MLN8054 a promising candidate for targeted cancer therapy.
Induces cell cycle arrest and apoptosis in cancer cells
MLN8054 has been shown to stop cancer cells from dividing and cause them to undergo apoptosis, or programmed cell death.
Potent activity against a range of cancer cell lines
MLN8054 has demonstrated the ability to inhibit the proliferation of various types of tumor cells in preclinical studies.
Ongoing research
Further studies are being conducted to explore the potential of MLN8054 as a therapeutic agent for cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 1253422-84-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,3,4,2 and 2 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1253422-84:
(9*1)+(8*2)+(7*5)+(6*3)+(5*4)+(4*2)+(3*2)+(2*8)+(1*4)=132
132 % 10 = 2
So 1253422-84-2 is a valid CAS Registry Number.
1253422-84-2Relevant academic research and scientific papers
5-piperazinyl-3-sulfonylindazoles as potent and selective 5-hydroxytryptamine-6 antagonists
Liu, Kevin G.,Robichaud, Albert J.,Bernotas, Ronald C.,Yan, Yinfa,Lo, Jennifer R.,Zhang, Mei-Yi,Hughes, Zoe A.,Huselton, Christine,Zhang, Guo Ming,Zhang, Jean Y.,Kowal, Dianne M.,Smith, Deborah L.,Schechter, Lee E.,Comery, Thomas A.
scheme or table, p. 7639 - 7646 (2011/02/21)
As part of our efforts to develop agents for CNS diseases, we have been focused on the 5-HT6 receptor in order to identify potent and selective ligands for cognitive enhancement. Herein we report the identification of a novel series of 5-piperazinyl-3-sulfonylindazoles as potent and selective 5-HT6 antagonists. The synthesis, SAR, and pharmacokinetic and pharmacological activities of some of the compounds including 3-(naphthalen-1-ylsulfonyl)-5-(piperazin-1-yl)-1H-indazole (WAY-255315 or SAM-315) will be described.
