744220-34-6Relevant academic research and scientific papers
Structure-activity relationships of a novel series of melanin-concentrating hormone (MCH) receptor antagonists
Arienzo, Rosa,Clark, David E.,Cramp, Sue,Daly, Stephen,Dyke, Hazel J.,Lockey, Peter,Norman, Dennis,Roach, Alan G.,Stuttle, Keith,Tomlinson, Maxine,Wong, Melanie,Wren, Stephen P.
, p. 4099 - 4102 (2004)
A new series of 2-aminoquinolines has been identified as antagonists of the melanin concentrating hormone receptor (MCH-1R). Syntheses and structure-activity relationships are described leading to a compound having low nanomolar activity against the receptor and demonstrating functional antagonism. Studies also showed that some of the compounds were selective against a range of other G protein-coupled receptors.
SUBSTITUTED QUINOLINES AS MCR MODULATORS
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Page/Page column 46, (2008/06/13)
Quinolines of formula (I) are useful as MCH mediators, and in the therapy of obesity.
