90772-83-1

Basic information

• Product Name: 6-Quinolinamine, 2-chloro-4-methyl-
• Synonyms: 2-chloro-4-methylquinolin-6-ylamine;6-amino-2-chlorolepidine;2-chloro-4-methyl-[6]quinolylamine;2-Chlor-4-methyl-6-amino-chinolin;6-amino-2-chloro-4-methylquinoline;6-Quinolinamine,2-chloro-4-methyl;2-Chlor-4-methyl-[6]chinolylamin
• CAS NO: 90772-83-1
• Molecular Formula: C10H9ClN2
• Molecular Weight: 192.648
• Mol File: 90772-83-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 154 °C
• Boiling Point: 372.2±37.0 °C(Predicted)
• Density: 1.307±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 6-Quinolinamine, 2-chloro-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Quinolinamine, 2-chloro-4-methyl-(90772-83-1)
• EPA Substance Registry System: 6-Quinolinamine, 2-chloro-4-methyl-(90772-83-1)

Safety Data

• Hazardous Substances Data: 90772-83-1(Hazardous Substances Data)

Upstream product

• 54965-59-2 2-chloro-4-methyl-6-nitroquinoline 

Downstream Products

• 744220-34-6 N-(2-chloro-4-methylquinolin-6-yl)-2-(4-trifluoromethylphenoxy)acetamide 
• 710328-16-8 N-(2-chloro-4-methylquinolin-6-yl)-2-(4-trifluoromethoxyphenoxy)acetamide 

Relevant articles and documents

PHOTOLYTIC RING-EXPANSIONS OF 4-AZIDOQUINOLINES AND 6-AZIDODIAZINES: SOME UNEXPECTED AZEPINE RING-OPENING REACTIONS

Photolysis of 6-azidoquinazoline in MeOH-KOMe-dioxan yields 8,9-dihydro-5,7-dimethoxy-5H-pyrimidoazepine (5) which on acid hydrolysis ring-opens to the pyrimidine-carbaldehyde (7).The mechanism of formation of this unexpected dimethoxypyrimido-azepine is discussed and related to previous similar results involving 6-azido-2,3-dihydrofuro- and 6-azido-2,3-dihydrothienoquinolines. In contrast, 6-azidoquinoxaline and 6-azido-2-chloro-4-methylquinoline on photolysis under similar conditions undergo ring expansion to the expected pyrazino- and pyridoazepines (22a) and (17) respectively.However, photolysis of the latter azide in MeOH-dioxan yields the 3-(2-pyridyl)propenonitrile derivative (18) in a reaction analogous to that undergone by 6-azidophenazine.

SUBSTITUTED QUINOLINES AS MCR MODULATORS

Quinolines of formula (I) are useful as MCH mediators, and in the therapy of obesity.