744266-99-7Relevant academic research and scientific papers
A facile preparation of N-methylpentan-l-amine: A key intermediate for ibandronate sodium
Reddyab, V V R M Krishna,Chintamani,Udaykiran,Madhusudhan,Mukkanti
experimental part, p. 1257 - 1260 (2010/12/24)
A facile preparation of N-methylpentan-l-amine, which is a key intermediate for the synthesis ibandronate sodium, an anti-osteoclast agent is described. This route is cost effective over the previous methods. Part of this work could be an easy access for the preparation of various N,N-alkyl or aryl amine derivatives.
REAGENT AND USE THEREOF FOR THE PRODUCTION OF BISPHOSPHONATES
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Page/Page column 9-10, (2008/12/05)
A new liquid reagent is disclosed in form of an ionic liquid containing phosphorous acid and a tertiary amine. The reagent can be used as a replacement of phosphorous acid, where the new reagent as a liquid reagent can be handled using usual equipment for handling liquids and the dosing of the reagent can therefore be controlled more precisely in industrial plants compared to phosphorous acid, which is a solid at ambient temperature. The new liquid reagent is particular suitable for the synthesis of bisphosphonates.
PROCESS FOR PREPARING IBANDRONATE
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Page/Page column 2, (2008/12/04)
The invention relates to a novel multi step synthesis of 3-(N-methyl-N-pentyl)amino-1-hydroxypropane-1,1-diphosphonic acid, monosodium salt, monohydrate, of the formula
CRYSTALLINE FORM A OF IBANDRONIC ACID AND PROCESS FOR THE PREPARATION
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Page/Page column 27-28, (2008/06/13)
The present invention relates crystalline Form A of Ibandronic acid having Formula (I) and a process for the preparation thereof.
Method for synthesizing bisphosphonate
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Page/Page column 3, (2008/06/13)
The invention relates to a novel multi step synthesis of 3-(N-methyl-N-pentyl) amino-1-hydroxypropane-1,1-diphosphonic acid, monosodium salt, monohydrate, of the formula
