25419-06-1

Usage

Uses

Used in Chemical Synthesis:
N-Methylpentylamine is used as a reactant for the synthesis of various organic compounds, such as N′-tert-butyl-N-methyl-N-pentylsulfamide and 1-methyl-3-(methylpentylamino)-4-(phenylseleno) 1H-pyrrole-2,5-dione (aminoarylselenated maleimide). It plays a crucial role in the formation of these compounds through different chemical reactions, such as the reaction with triethylammonium N-tert-butylsulfamate in the presence of triphenylphosphine oxide and trifluoromethanesulfonic anhydride, and the Cu-catalyzed four-component coupling reaction with methyl maleimide, selenium powder, and iodobenzene.
Used in Material Science:
N-Methylpentylamine is used as an organic structure-directing agent in the preparation of microporous silicoaluminophosphate (SAPO) molecular sieves. Its unique molecular structure allows it to guide the formation of specific pore structures in these materials, which are important for various industrial applications, such as gas separation, catalysis, and ion exchange.

InChI:InChI=1/C6H15N/c1-3-4-5-6-7-2/h7H,3-6H2,1-2H3

Upstream product

• 77223-58-6 N-methyl,N-(n-pentyl) benzylamine 
• 110-58-7 n-Pentylamine 
• 74-88-4 methyl iodide 
• 680-31-9 N,N,N,N,N,N-hexamethylphosphoric triamide 
• 109-72-8 n-butyllithium 
• 74-89-5 methylamine 
• 109-52-4 valeric acid 
• 106-98-9 1-butylene 
• 51-80-9 bis-(dimethylamino)methane 
• 6225-10-1 N-methylpentanamide 
• 22710-00-5 N-pentyl-1-phenylmethanimine 
• 5187-82-6 (ethoxycarbonylmethyl)dimethylsulfonium bromide 
• 102102-20-5 N-chloro-n-pentylmethylamine 
• 118793-06-9 Methyl-pent-(E)-ylidene-amine 

Downstream Products

• 52317-68-7 3-(2,4-Dimethyl-phenyl)-1-methyl-1-pentyl-thiourea 
• 52403-61-9 3-(4-Chloro-2-methyl-phenyl)-1-methyl-1-pentyl-thiourea 
• 64796-60-7 3-(m-Chloro-α,α-dimethylbenzyl)-1-methyl-1-pentylurea 
• 59708-22-4 C₁₃H₂₀N₄O 
• 1026238-29-8 3-(2-Dimethylamino-6-methoxy-phenyl)-1-methyl-1-pentyl-urea 
• 149079-94-7 3-(2-{(1S,2R,3S,4R)-3-[4-(Methyl-pentyl-carbamoyl)-oxazol-2-yl]-7-oxa-bicyclo[2.2.1]hept-2-ylmethyl}-phenyl)-propionic acid methyl ester 
• 61500-82-1 N-Methyl-N-n-pentylcarbamoyl chloride 
• 765-48-0 1,2-dimethylpyrrolidine 
• 1026037-00-2 3-(2-Dimethylamino-6-hydroxy-phenyl)-1-methyl-1-pentyl-urea 
• 744266-99-7 methyl 3-(N-methyl-N-pentylamino)propanoate 
• 85785-22-4 S-benzyl methyl-n-pentylthiolcarbamate 
• 918893-53-5 10-(N-methyl-N-pentylamino)-decanoic acid (4-nitro-3-trifluoromethyl-phenyl)-amide 
• 1060748-93-7 C₂₂H₂₄N₂O₂ 
• 1060749-07-6 C₂₂H₂₃ClN₂O₂ 

Relevant academic research and scientific papers

Photometric Characterization of the Reductive Amination Scope of the Imine Reductases from Streptomyces tsukubaensis and Streptomyces ipomoeae

Imine reductases (IREDs) have emerged as promising enzymes for the asymmetric synthesis of secondary and tertiary amines starting from carbonyl substrates. Screening the substrate specificity of the reductive amination reaction is usually performed by time-consuming GC analytics. We found two highly active IREDs in our enzyme collection, IR-20 from Streptomyces tsukubaensis and IR-Sip from Streptomyces ipomoeae, that allowed a comprehensive substrate screening with a photometric NADPH assay. We screened 39 carbonyl substrates combined with 17 amines as nucleophiles. Activity data from 663 combinations provided a clear picture about substrate specificity and capabilities in the reductive amination of these enzymes. Besides aliphatic aldehydes, the IREDs accepted various cyclic (C4–C8) and acyclic ketones, preferentially with methylamine. IR-Sip also accepted a range of primary and secondary amines as nucleophiles. In biocatalytic reactions, IR-Sip converted (R)-3-methylcyclohexanone with dimethylamine or pyrrolidine with high diastereoselectivity (>94–96 % de). The nucleophile acceptor spectrum depended on the carbonyl substrate employed. The conversion of well-accepted substrates could also be detected if crude lysates were employed as the enzyme source.

PROCESS FOR THE SYNTHESIS OF IBANDRONATE SODIUM

The present invention relates to an improved process for the synthesis of Ibandronate sodium of formula (I). The present invention also provides novel processes for the synthesis of 3-[N-(methylpentyl)amino]propionic acid (III).

A facile preparation of N-methylpentan-l-amine: A key intermediate for ibandronate sodium

A facile preparation of N-methylpentan-l-amine, which is a key intermediate for the synthesis ibandronate sodium, an anti-osteoclast agent is described. This route is cost effective over the previous methods. Part of this work could be an easy access for the preparation of various N,N-alkyl or aryl amine derivatives.

CRYSTALLINE FORM A OF IBANDRONIC ACID AND PROCESS FOR THE PREPARATION

The present invention relates crystalline Form A of Ibandronic acid having Formula (I) and a process for the preparation thereof.

PROCESS FOR PREPARING IBANDRONATE

The invention relates to a novel multi step synthesis of 3-(N-methyl-N-pentyl)amino-1-hydroxypropane-1,1-diphosphonic acid, monosodium salt, monohydrate, of the formula

2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION

The present invention has its object to provide a 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine derivative represented with the Formula (1) , or the pharmaceutically acceptable salt, which is effective as a therapeutic and prophylactic agent for diabetes, diabetic nephropathy, or glomerulosclerosis.

Method for synthesizing bisphosphonate

The invention relates to a novel multi step synthesis of 3-(N-methyl-N-pentyl) amino-1-hydroxypropane-1,1-diphosphonic acid, monosodium salt, monohydrate, of the formula

Preparation process of aminoacetamide derivative

Disclosed herein are novel processes for preparing aminoacetamide derivatives, wherein: (1) a secondary amine is reacted with a 2-haloacetamide in the presence or absence of at least one solvent selected from water, lower alcohols, aromatic solvents and acetic acid esters; (2) an N-benzylideneamine derivative is reacted with dimethyl sulfate or diethyl sulfate to form a secondary amine, and this secondary amine is then reacted with a 2-haloacetamide; and (3) a primary amine is reacted with benzaldehyde to form an N-benzylideneamine derivative, this product is then reacted with dimethyl sulfate or diethyl sulfate to form a secondary amine, and this secondary amine is further reacted with a 2-haloacetamide. The 2-aminoacetamide derivatives are useful as intermediates for the preparation of novel antibiotics.

Transformation of Monoamine Oxidase-B Primary Amine Substrates into Time-Dependent Inhibitors. Tertiary Amine Homologues of Primary AMine Substrates

A family of N-methylated and N,N-dimethylated alkyl and arylalkylamines was prepared and more than half of the analogues were shown to be time-dependent pseudo-first-order inhibitors of monoamine oxidase-B.Some of the time-dependent inactivators were reversible and others were irreversible with respect to prolonged dialysis following inactivation.Partition ratios ranged from zero to 11 000.These results are rationalized in terms of a combination of an inductive effect and a stereoelectronic effect as a result of hindered rotation of an active site covalent adduct.A molecualr mechanics calculation indicates that there is at least 10 kcal/mol of torsional energy to be overcome in order for the enzyme adduct to be released.These findings show that tertiary amine homologues of primary amine substrates of monoamino oxidase are time-dependent inhibitors, and this should be useful in the design of new inactivators of this enzyme.

ELECTROCHEMICAL REDUCTIVE AMINATION. II. AMINATION OF ALIPHATIC ALDEHYDES WITH PRIMARY AMINES

The formation of a secondary amine by the electrolysis of an aqueous solution containing an aldehyde and a primary amine was studied.The formation of the secondary amines passes through the intermediate stage of an aldimine.The highest yield of secondary amine is attained at a molar ratio of primary amine to aldehyde of 1.2:1.As electrode material lead, cadmium, zinc, and copper may be used.As supporting electrolyte a phosphate buffer with a pH close to the pKa of the primary amine is recommended.By the method developed 32 amines with various structures were synthesized.