25419-06-1

Basic information

• Product Name: N-Methylpentylamine
• Synonyms: AMYLMETHYLAMINE;1-Pentanamine,N-methyl-;Methylamylamine;N-Amylmethylamine;N-Amyl-N-methylamine;N-Methyl-1-pentanamine;N-Methylamylamine;N-Methyl-n-amylamine
• CAS NO: 25419-06-1
• Molecular Formula: C₆H₁₅N
• Molecular Weight: 101.19
• EINECS: 246-966-9
• Product Categories: Polyamines;Amines;C2 to C6;Nitrogen Compounds;NULL
• Mol File: 25419-06-1.mol
• Article Data: 15

Chemical Properties

• Melting Point: -87.87°C (estimate)
• Boiling Point: 116-118 °C(lit.)
• Flash Point: 55 °F
• Appearance: /
• Density: 0.738 g/mL at 25 °C(lit.)
• Vapor Pressure: 18.5mmHg at 25°C
• Refractive Index: n20/D 1.41(lit.)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 10.84±0.10(Predicted)
• BRN: 1731333
• CAS DataBase Reference: N-Methylpentylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methylpentylamine(25419-06-1)
• EPA Substance Registry System: N-Methylpentylamine(25419-06-1)

Safety Data

• Hazard Codes: F,C
• Statements: 11-22-34
• Safety Statements: 26-36/37/39-45-33-29-16-9
• RIDADR: UN 2924 3/PG 2
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 25419-06-1(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

N-Methylpentylamine can be used as an organic structure-directing agent in the preparation of microporous silicoaluminophosphate (SAPO) molecular sieves. It can also be used as a reactant to synthesize: N′-tert-butyl-N-methyl-N-pentylsulfamide by reacting with triethylammonium N-tert-butylsulfamate in the presence of triphenylphosphine oxide and trifluoromethanesulfonic anhydride.1-methyl-3-(methylpentylamino)-4-(phenylseleno) 1H-pyrrole-2,5-dione (aminoarylselenated maleimide) by Cu-catalyzed four-component coupling reaction with methyl maleimide, Se powder and iodobenzene.

InChI:InChI=1/C6H15N/c1-3-4-5-6-7-2/h7H,3-6H2,1-2H3

Upstream product

• 77223-58-6 N-methyl,N-(n-pentyl) benzylamine 
• 110-58-7 n-Pentylamine 
• 74-88-4 methyl iodide 
• 680-31-9 N,N,N,N,N,N-hexamethylphosphoric triamide 
• 109-72-8 n-butyllithium 
• 74-89-5 methylamine 
• 109-52-4 valeric acid 
• 106-98-9 1-butylene 
• 51-80-9 bis-(dimethylamino)methane 
• 6225-10-1 N-methylpentanamide 
• 22710-00-5 N-pentyl-1-phenylmethanimine 
• 5187-82-6 (ethoxycarbonylmethyl)dimethylsulfonium bromide 
• 102102-20-5 N-chloro-n-pentylmethylamine 
• 118793-06-9 Methyl-pent-(E)-ylidene-amine 

Downstream Products

• 85785-22-4 S-benzyl methyl-n-pentylthiolcarbamate 
• 128479-57-2 N-amyl-N-methyl-p-toluidine 
• 1616976-64-7 N,2-dimethyl-N-pentyl-3-(2-phenylquinolin-4-yl)propanamide 
• 1184845-05-3 4-nitrophenyl methyl(n-pentyl)carbamate 
• 1060748-98-2 C₂₂H₂₂Cl₂N₂O₂ 
• 1060749-02-1 C₂₂H₂₃ClN₂O₂ 
• 1060749-07-6 C₂₂H₂₃ClN₂O₂ 
• 1060748-93-7 C₂₂H₂₄N₂O₂ 
• 918893-53-5 10-(N-methyl-N-pentylamino)-decanoic acid (4-nitro-3-trifluoromethyl-phenyl)-amide 
• 744266-99-7 methyl 3-(N-methyl-N-pentylamino)propanoate 
• 1026037-00-2 3-(2-Dimethylamino-6-hydroxy-phenyl)-1-methyl-1-pentyl-urea 
• 765-48-0 1,2-dimethylpyrrolidine 

Relevant articles and documents

Photometric Characterization of the Reductive Amination Scope of the Imine Reductases from Streptomyces tsukubaensis and Streptomyces ipomoeae

Imine reductases (IREDs) have emerged as promising enzymes for the asymmetric synthesis of secondary and tertiary amines starting from carbonyl substrates. Screening the substrate specificity of the reductive amination reaction is usually performed by time-consuming GC analytics. We found two highly active IREDs in our enzyme collection, IR-20 from Streptomyces tsukubaensis and IR-Sip from Streptomyces ipomoeae, that allowed a comprehensive substrate screening with a photometric NADPH assay. We screened 39 carbonyl substrates combined with 17 amines as nucleophiles. Activity data from 663 combinations provided a clear picture about substrate specificity and capabilities in the reductive amination of these enzymes. Besides aliphatic aldehydes, the IREDs accepted various cyclic (C4–C8) and acyclic ketones, preferentially with methylamine. IR-Sip also accepted a range of primary and secondary amines as nucleophiles. In biocatalytic reactions, IR-Sip converted (R)-3-methylcyclohexanone with dimethylamine or pyrrolidine with high diastereoselectivity (>94–96 % de). The nucleophile acceptor spectrum depended on the carbonyl substrate employed. The conversion of well-accepted substrates could also be detected if crude lysates were employed as the enzyme source.

PROCESS FOR THE SYNTHESIS OF IBANDRONATE SODIUM

The present invention relates to an improved process for the synthesis of Ibandronate sodium of formula (I). The present invention also provides novel processes for the synthesis of 3-[N-(methylpentyl)amino]propionic acid (III).

CRYSTALLINE FORM A OF IBANDRONIC ACID AND PROCESS FOR THE PREPARATION

The present invention relates crystalline Form A of Ibandronic acid having Formula (I) and a process for the preparation thereof.