74443-00-8

Basic information

• Product Name: ethyl 5-cyano-6-oxo-1,6-dihydropyridine-3-carboxylate
• Synonyms: ethyl 5-cyano-6-oxo-1,6-dihydropyridine-3-carboxylate
• CAS NO: 74443-00-8
• Molecular Formula: C9H8N2O3
• Molecular Weight: 192.17142
• Mol File: 74443-00-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 5-cyano-6-oxo-1,6-dihydropyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-cyano-6-oxo-1,6-dihydropyridine-3-carboxylate(74443-00-8)
• EPA Substance Registry System: ethyl 5-cyano-6-oxo-1,6-dihydropyridine-3-carboxylate(74443-00-8)

Safety Data

• Hazardous Substances Data: 74443-00-8(Hazardous Substances Data)

Upstream product

• 160729-80-6 ethyl 6-hydroxy-5-iodonicotinate 
• 557-21-1 dicyanozinc 
• 4869-46-9 1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde 
• 107-91-5 cyanoacetic acid amide 
• 141-52-6 sodium ethanolate 
• 74442-99-2 5-(2-Carbamoyl-2-cyanovinyl)-1,3-dimethyluracil 

Relevant articles and documents

(3,4-DISUBSTITUTED)PROPANOIC CARBOXYLATES AS S1P (EDG) RECEPTOR AGONISTS

The present invention encompasses compounds of Formula A: A as well as the pharmaceutically acceptable salts thereof. The compounds are S1P1/Edg1 receptor agonists and thus have immunosuppressive, anti-inflammatory and hemostatic activities by modulating leukocyte trafficking, sequestering lymphocytes in secondary lymphoid tissues, and enhancing vascular integrity. The invention is also directed to pharmaceutical compositions containing such compounds and methods of treatment or prevention.

A Novel Ring Transformation of Uracil into the Benzene Ring System

Reaction of 5-formyl-1,3-dimethyluracil with some active methylene compounds in the presence of base causes novel ring transformations to give the p-hydroxybenzoates and the nicotinate.