74447-38-4

Usage

Uses

Used in Pharmaceutical Industry:
4-(2-Hydroxyethyl)phenyl Methanesulfonate is used as a key intermediate for the synthesis of various pharmaceuticals. Its ability to serve as a leaving group in reactions makes it a valuable component in the development of new drugs.
Used in Dye Industry:
In the dye industry, 4-(2-Hydroxyethyl)phenyl Methanesulfonate is used in the production of different types of dyes. Its chemical properties allow for the creation of a wide range of colorants used in various applications.
Used in Personal Care and Cosmetic Industries:
4-(2-Hydroxyethyl)phenyl Methanesulfonate is used as a component in the production of various surfactants and additives in the personal care and cosmetic industries. Its versatility in organic synthesis contributes to the development of innovative products for these markets.
Used in Biochemistry and Medicinal Chemistry Research:
Due to its ability to modify and functionalize organic compounds, 4-(2-Hydroxyethyl)phenyl Methanesulfonate has potential applications in the fields of biochemistry and medicinal chemistry. It can be utilized in the development of new compounds and the study of biological processes.

Upstream product

• 74447-37-3 4-methylsulphonyloxyphenylacetaldehyde 
• 74447-40-8 2-(4-hydroxyphenyl)-1,1-dimethoxyethane 
• 74447-36-2 1-(Methylsulfonyloxy)-2-[4-(methylsulfonyloxy)phenyl]ethane 
• 836-42-0 4-benzyloxybenzyl chloride 
• 74447-42-0 2-(4-benzyloxybenzyl)-1,3-dithian 
• 74447-41-9 2-(4-benzyloxyphenyl)-1,1-dimethoxyethane 
• 74447-39-5 1,1-dimethoxy-2-(4-methylsulphonyloxyphenyl)ethane 
• 836-43-1 4-benzyloxybenzyl alcohol 

Downstream Products

• 501-94-0 p-hydroxyphenethyl alcohol 
• 74447-32-8 O,O-dibenzoyltyrosol 
• 74447-36-2 1-(Methylsulfonyloxy)-2-[4-(methylsulfonyloxy)phenyl]ethane 
• 74447-37-3 4-methylsulphonyloxyphenylacetaldehyde 
• 1007893-80-2 (7-bromo-9H-pyrido[3,4-b]indol-1-yl)(3,5-dibromo-4-hydroxyphenyl)methanone 
• 1007893-79-9 (6-bromo-9H-pyrido[3,4-b]indol-1-yl)(3,5-dibromo-4-hydroxyphenyl)methanone 
• 1007893-78-8 (3,5-dibromo-4-hydroxyphenyl)(9H-pyrido[3,4-b]indol-1-yl)methanone 
• 1435263-19-6 (7-bromo-9H-pyrido[3,4-b]indol-1-yl)(4-hydroxyphenyl)methanone 
• 1007893-75-5 (6-bromo-9H-pyrido[3,4-b]indol-1-yl)(4-hydroxyphenyl)methanone 
• 1007893-74-4 (4-hydroxyphenyl)(9H-pyrido[3,4-b]indol-1-yl)methanone 
• 1435263-88-9 4-(7-bromo-9H-pyrido[3,4-b]indole-1-carbonyl)phenyl methanesulfonate 
• 1435263-75-4 4-(6-bromo-9H-pyrido[3,4-b]indole-1-carbonyl)phenyl methanesulfonate 
• 1435263-15-2 4-(9H-pyrido[3,4-b]indole-1-carbonyl)phenyl methanesulfonate 
• 1435263-69-6 4-((7-bromo-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)methyl)phenyl methanesulfonate 

Relevant academic research and scientific papers

Selective hydrolysis of methanesulfonate esters

The pH dependence of the hydrolysis of 4-{2-[(methylsulfonyl)oxy]ethyI} phenyl methanesulfonate, 1, and two carboxylate esters, ethyl 2(S)-ethoxy-3-(4-hydroxyphenyl)propionate, 2 and (2S)-2-ethoxy-3-[4-(2-{4- [(methylsulfonyl)oxy]phenyl}ethoxy)phenyl]propanoate, 3, has been studied with a view to the selective removal of any remaining 1, following coupling with 2 to generate 3 in water at 95 °C (Scheme 1). It is shown that reduction of pH from that of the reaction conditions (pH ≈ 10) to pH 7-8 has little effect on the hydrolysis of 1, which is dominated by the water rate over this pH range, but reduces the rate of hydrolysis of the carboxylate ester group by 3 orders of magnitude (pH 7). This very strong quantitative difference in the response of the two types of ester group to pH change allows complete removal of 1 at low pH without measurable loss to the product ester, 3. The conclusions should be generally applicable to the removal of potentially genotoxic alkyl esters of methane sulfonic acid in the presence of carboxylic esters and other base-sensitive groups.