74457-54-8

Basic information

• Product Name: 1-(1-acetoxyethyl)-2,2-difluoro-1-methyl-3-phenylcyclopropane
• CAS NO: 74457-54-8
• Molecular Weight: 254.277
• Mol File: 74457-54-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(1-acetoxyethyl)-2,2-difluoro-1-methyl-3-phenylcyclopropane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-acetoxyethyl)-2,2-difluoro-1-methyl-3-phenylcyclopropane(74457-54-8)
• EPA Substance Registry System: 1-(1-acetoxyethyl)-2,2-difluoro-1-methyl-3-phenylcyclopropane(74457-54-8)

Safety Data

• Hazardous Substances Data: 74457-54-8(Hazardous Substances Data)

Upstream product

• 74457-39-9 acetic acid (E)-1,2-dimethyl-3-phenyl-allyl ester 
• 1895-39-2 sodium chlorodifluoroacetate 

Downstream Products

• 343778-51-8 1-(2,2-Difluoro-1-methyl-3-phenyl-cyclopropyl)-ethanone 
• 82045-08-7 1-acetyl-2,2-difluoro-1-methyl-3-phenylcyclopropane 
• 82045-16-7 3-[2-Phenyl-4H-benzo[1,4]thiazin-(3Z)-ylidene]-butan-2-one 
• 74457-52-6 3-[2-Phenyl-4H-benzo[1,4]thiazin-(3E)-ylidene]-butan-2-one 

Relevant articles and documents

Studies on Organic Fluorine Compounds. 38. Ring-Opening Reactions of gem-Difluorocyclopropyl Ketones with Nucleophiles

Syntheses of gem-difluorocyclopropyl ketones (3a-d) and their reactions with nucleophiles are described.Ring-opening reaction of 3a,c,d having a hydrogen substituent at C1 adjacent to the carbonyl group with a methanolate anion gave carboxylic acid derivatives derived from C1-C2 bond scission (between the carbon atom with an acyl group and the carbon atom with fluorine substituents).On the other hand, reaction of 3a-c with a thiolate anion resulted in the C1-C3 bond cleavage (carbon-carbon bond opposite to the difluoromethylene group).