74457-39-9

Upstream product

• 945030-93-3 2-methyl-1-phenylbut-2-enyl acetate 
• 123290-15-3 2-butenyl-2-methyl-1-phenyl-1-ol 
• 100-52-7 benzaldehyde 

Downstream Products

• 82045-08-7 1-acetyl-2,2-difluoro-1-methyl-3-phenylcyclopropane 
• 74457-54-8 1-(1-acetoxyethyl)-2,2-difluoro-1-methyl-3-phenylcyclopropane 
• 74457-54-8 Acetic acid 1-(2,2-difluoro-1-methyl-3-phenyl-cyclopropyl)-ethyl ester 

Relevant academic research and scientific papers

Silica gel-mediated rearrangement of allylic acetates. Application to the synthesis of 1,3-enynes

Silica gel was found to efficiently promote the rearrangement of allylic acetates into their most stable regioisomers under microwave irradiation. The reaction is easy to perform and eco-friendly. This method was applied to the metal-free synthesis of 1,3-enynes.

[(NHC)Au1]-catalyzed rearrangement of allylic acetates

Equation Presented [(NHC)AuCl] complexes (NHC = N-heterocyclic carbene), in conjunction with a silver salt, were found to efficiently catalyze the rearrangement of allylic acetates under both conventional and microwave-assisted heating. The optimization of several reaction parameters (solvent, silver salt, and ligand) as well as a study of the reaction scope are reported. The steric hindrance of the ligand bound to gold was found crucial for the outcome of the reaction as only extremely bulky ligands permitted the isomerization.