74466-82-3Relevant articles and documents
Synthesis and anti-angiogenic activity of 6-(1,2,4-thiadiazol-5-yl)-3-amino pyridazine derivatives
Bongartz, Jean-Pierre,Stokbroekx, Raymond,Van der Aa, Marcel,Luyckx, Marcel,Willems, Marc,Ceusters, Marc,Meerpoel, Lieven,Smets, Gerda,Jansen, Tine,Wouters, Walter,Bowden, Charlie,Valletta, Lisa,Herb, Mark,Tominovich, Rose,Tuman, Robert
, p. 589 - 591 (2007/10/03)
General screening for inhibitors of microvessel growth in vitro in the rat aortic ring assay led to the discovery of a novel series of thiadiazole pyridazine compounds with potential anti-angiogenic activity. Chemical optimization produced orally active compounds with potent in vitro and in vivo anti-angiogenesis and anti-tumor activities.