74466-82-3Relevant academic research and scientific papers
Synthesis and anti-angiogenic activity of 6-(1,2,4-thiadiazol-5-yl)-3-amino pyridazine derivatives
Bongartz, Jean-Pierre,Stokbroekx, Raymond,Van der Aa, Marcel,Luyckx, Marcel,Willems, Marc,Ceusters, Marc,Meerpoel, Lieven,Smets, Gerda,Jansen, Tine,Wouters, Walter,Bowden, Charlie,Valletta, Lisa,Herb, Mark,Tominovich, Rose,Tuman, Robert
, p. 589 - 591 (2007/10/03)
General screening for inhibitors of microvessel growth in vitro in the rat aortic ring assay led to the discovery of a novel series of thiadiazole pyridazine compounds with potential anti-angiogenic activity. Chemical optimization produced orally active compounds with potent in vitro and in vivo anti-angiogenesis and anti-tumor activities.
New Synthesis of 1,2,4-Thiadiazoles
Lin, Yang-i,Lang, S. A.,Petty, Sharon R.
, p. 3750 - 3753 (2007/10/02)
A new synthesis of 1,2,4-thiadiazoles has been developed.N'-(Thioaroyl)- (and N'-arylthiocarbamoyl-) N,N-dimethylamidines, which were prepared in excellent yields by reactions of thioamides (and thioureas) with N,N-dimethylalkanamide dimethyl acetals, rea
