74467-01-9

Basic information

• Product Name: (Z)-2-Methoxybenzoyl chloride oxime
• Synonyms: (Z)-2-methoxybenzoyl chloride oxime;N-Hydroxy-2-methoxybenzimidoyl chloride
• CAS NO: 74467-01-9
• Molecular Formula: C₈H₈ClNO₂
• Molecular Weight: 185.61
• Mol File: 74467-01-9.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (Z)-2-Methoxybenzoyl chloride oxime(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-2-Methoxybenzoyl chloride oxime(74467-01-9)
• EPA Substance Registry System: (Z)-2-Methoxybenzoyl chloride oxime(74467-01-9)

Safety Data

• Hazardous Substances Data: 74467-01-9(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(Z)-2-Methoxybenzoyl chloride oxime is used as a reagent in the preparation of amides and various other organic compounds. Its high reactivity makes it a valuable component in the synthesis of a wide range of organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (Z)-2-Methoxybenzoyl chloride oxime is used as an intermediate in the synthesis of various drugs and pharmaceutical compounds. Its ability to form amides and other organic compounds contributes to the development of new medications and therapeutic agents.
Used in Chemical Research:
(Z)-2-Methoxybenzoyl chloride oxime is also utilized in chemical research for studying reaction mechanisms and exploring new synthetic pathways. Its reactivity and versatility make it a valuable tool for researchers in the field of organic chemistry.
Used in Material Science:
In material science, (Z)-2-Methoxybenzoyl chloride oxime can be employed in the development of new materials with specific properties, such as polymers, coatings, and adhesives. Its ability to form amides and other organic compounds can contribute to the creation of materials with unique characteristics and applications.

Upstream product

• 29577-53-5 2-Methoxy-benzaldehyde oxime 
• 135-02-4 ortho-anisaldehyde 
• 128-09-6 N-chloro-succinimide 

Downstream Products

• 93041-44-2 3-(2-methoxyphenyl)-5-methylisoxazole-4-carboxylic acid 
• 160280-04-6 Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-(N-hydroxy-2-methoxy-benzimidoylsulfanyl)-tetrahydro-pyran-3-yl ester 
• 3288-04-8 1-isothiocyanato-2-methoxybenzene 
• 89109-66-0 O-benzoyl-2-methoxybenzohydroximoyl chloride 
• 89109-67-1 O-4-nitrobenzoyl-2-methoxybenzohydroximoyl chloride 
• 138535-64-5 5-(1,2-O-isopropylidene-α-D-xylo-tetrafuranos-4-yl)-3-(2-methoxyphenyl)-2-isoxazoline 
• 138535-64-5 (3aR,5S,6S,6aR)-5-[(S)-3-(2-Methoxy-phenyl)-4,5-dihydro-isoxazol-5-yl]-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-ol 
• 345967-78-4 5-hydroxymethyl-3-(o-methoxyphenyl)isoxazole 
• 495417-30-6 ethyl 3-(2-methoxyphenyl)-5-methylisoxazole-4-carboxylate 
• 748771-24-6 5-(4-chloro-phenyl)-3-(2-methoxy-phenyl)-isoxazole 
• 169814-26-0 3-(2-methoxy-phenyl)-6,7-dihydro-5H-benzo[d]isoxazol-4-one 
• 140946-66-3 ethyl 3-(2-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxylate 
• 1027595-88-5 3-(2-methoxy-phenyl)-4,5-dihydro-isoxazole-5-carbonyl chloride 
• 508182-19-2 3-(2-methoxyphenyl)-4,5-dihydroisoxazole-5-carboxylic acid 

Relevant articles and documents

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SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION

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Discovery of Natural Product-Based Fungicides (II): Semisynthesis and Biological Activity of Sarisan Attached 3-Phenylisoxazolines as Antifungal Agents

Many phytopathogenic fungi cause severe damage to crop yields. In continuation of our research aimed at the discovery and development of natural products-based fungicides, a series of thirty-one sarisan attached 3-phenylisoxazolines were synthesized and evaluated for their antifungal activities against five phytopathogenic fungi (B. cinerea, C. lagenarium, A. solani, F. solani, and F. graminearum). Among all title sarisan derivatives, compounds IV2, IV14 and IV23 showed potent antifungal activity against some phytopathogenic fungi. In particular, compound IV2 exhibited a broad-spectrum and more potent antifungal activity against A. solani, F. solani, and F. graminearum than the commercial fungicide Hymexazol. In addition, compounds IV2, IV14 and IV23 also displayed relative low toxicity on normal NRK-52E cells. This work will give some insights into the development of sarisan derivatives as new fungicide candidates in plant protection.

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An enantioselective [3 + 2] cycloaddition reaction between nitrile oxides and transiently generated enolates of α-keto esters has been developed. The catalyst system was found to be compatible with in situ nitrile oxide-generation conditions. A versatile array of nitrile oxides and α-keto esters could participate in the cycloaddition, providing novel 5-hydroxy-2-isoxazolines in high chemical yield with high levels of diastereo- and enantioselectivity. Notably, the optimal reaction conditions circumvented concurrent reactions via O-imidoylation and hetero-[3 + 2] pathways.

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