66046-34-2

Usage

Uses

Used in Coordination Chemistry:
(E)-N-hydroxy-1-[4-(trifluoromethyl)phenyl]methanimine is used as a ligand for forming strong complexes with metal ions, which is crucial in coordination chemistry.
Used in Organic Synthesis:
In the field of organic synthesis, (E)-N-hydroxy-1-[4-(trifluoromethyl)phenyl]methanimine serves as a reagent due to its ability to form stable complexes with metal ions, facilitating various chemical reactions and syntheses.
Used in Drug Development:
(E)-N-hydroxy-1-[4-(trifluoromethyl)phenyl]methanimine is studied for its potential pharmacological and medicinal properties, making it an interesting target for drug development.
Used in Bioinorganic Chemistry Research:
(E)-N-hydroxy-1-[4-(trifluoromethyl)phenyl]methanimine is also utilized in bioinorganic chemistry research, where its metal-chelating properties can be explored for various applications, including the study of metalloenzymes and metal-based drug interactions.

Upstream product

• 402-43-7 p-trifluoromethylphenyl bromide 
• 68-12-2 N,N-dimethyl-formamide 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 349-95-1 4-(trifluoromethyl)benzylic alcohol 
• 10576-12-2 ethyl acetohydroximate 
• 123-11-5 4-methoxy-benzaldehyde 
• 96-29-7 ethyl methyl ketone oxime 
• 3300-51-4 p-Trifluoromethylbenzylamine 

Downstream Products

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 3300-51-4 p-Trifluoromethylbenzylamine 
• 74467-05-3 N-hydroxy-4-(trifluoromethyl)benzenecarboximidoyl chloride 
• 89902-86-3 2-(2-cyanoethyl)-3-(p-trifluoromethylphenyl)-4-cyanoisoxazolidine 
• 89902-84-1 2-(2-cyanoethyl)-3-(p-trifluoromethylphenyl)-5-cyanoisoxazolidine 
• 89902-84-1 2-(2-cyanoethyl)-3-(p-trifluoromethylphenyl)-5-cyanoisoxazolidine 
• 89902-87-4 2-(2-methoxycarbonylethyl)-3-(p-trifluoromethylphenyl)-5-methoxycarbonylisoxazolidine 
• 89902-88-5 2-(2-methoxycarbonylethyl)-3-(p-trifluoromethylphenyl)-4-methoxycarbonylisoxazolidine 
• 89902-88-5 2-(2-methoxycarbonylethyl)-3-(p-trifluoromethylphenyl)-4-methoxycarbonylisoxazolidine 
• 1645-65-4 4-(trifluoromethyl)phenyl isothiocyanate 
• 111991-14-1 2-(4-trifluoromethylphenyl)oxirane 
• 80751-59-3 2-[2-(2-Chloro-3,4-dimethoxy-phenyl)-ethylamino]-1-(4-trifluoromethyl-phenyl)-ethanol 
• 613240-24-7 5-chloromethyl-3-(4-trifluoromethyl-phenyl)-isoxazole 
• 1891-90-3 p-trifluoromethylbenzamide 

Relevant academic research and scientific papers

A Transition-Metal-Free One-Pot Cascade Process for Transformation of Primary Alcohols (RCH2OH) to Nitriles (RCN) Mediated by SO2F2

A new transition-metal-free one-pot cascade process for the direct conversion of alcohols to nitriles was developed without introducing an “additional carbon atom”. This protocol allows transformations of readily available, inexpensive, and abundant alcohols to highly valuable nitriles.

Pt-catalyzed O-silylation of oximes by tri-substituted organosilanes

Silylated derivatives of oximes are important intermediates in organic synthesis, and have found application in the preparation of various nitrogen containing compounds including nitriles, amines, nitrones, and hydroxylamines. An efficient method for the

Facile one-pot preparation of 5-aryltetrazoles and 3-arylisoxazoles from aryl bromides

The successive treatment of aryl bromides with n-BuLi, DMF, hydroxylamine hydrochloride, and finally diphenylphosphoryl azide provided efficiently the corresponding 5-aryltetrazoles in good to moderate yields. Similarly, the successive treatment of aryl bromides with n-BuLi, DMF, hydroxylamine hydrochloride, and finally diethyl acetylenedicarboxylate and Oxone provided efficiently the corresponding diethyl 3-arylisoxazole-4,5-dicarboxylates in good to moderate yields. Aromatic aldoximes are the key intermediates in both reactions, and 5-aryltetrazoles and 3-arylisoxazoles could be obtained from aryl bromides in one pot under transition-metal-free conditions.

A mild system for synthesis of aldoximes and ketoximes in the presence of N-hydroxyphthalimide in aqueous system

An efficient method for synthesis of oximes from aldehydes or ketones with N-hydroxyphthalimide or N-hydroxysuccinimide in water has been described. It is the first time to utilize NHPI as an oximation reagent to synthesize aldoximes and ketoximes from the corresponding organic carbonyl compounds without other reagents. The reaction tolerates various functional groups and affords the corresponding oximes in 76%–98% yields. The by-product phthalic acid can be recycled from the system. In addition, this method has been successfully applied to the synthesis of the precursor of some pharmacologically active amide molecules.

Novel chemoenzymatic oxidation of amines into oximes based on hydrolase-catalysed peracid formation

The efficient transformation of benzylamines into the corresponding oximes has been described by means of a chemoenzymatic process. This strategy is based on a two-step sequence developed in one-pot at 30 °C and atmospheric pressure. First, the formation of a reactive peracid intermediate occurs by means of a lipase-catalysed perhydrolysis reaction, and then this peracid acts as a chemical oxidising agent of the amines. A total of nine ketoximes were isolated in high purity after a simple extraction protocol (90-98% isolated yield), while for the eleven synthesised aldoximes a further column chromatography purification was required (71-82% isolated yield). In all cases excellent selectivities were attained, offering a practical method for amine oxidation in short reaction times (1 hour). The environmental impact of the process was analysed and compared with a recently published alternative chemical synthesis, finding for this metric a good E-factor value.

CuH-Catalyzed Regioselective Intramolecular Hydroamination for the Synthesis of Alkyl-Substituted Chiral Aziridines

This report details a general and enantioselective means for the synthesis of alkyl-substituted aziridines. This protocol offers a direct route for the synthesis of alkyl-substituted chiral aziridines from achiral starting materials. Readily accessed ally

METHOD FOR PRODUCING ALDOXIME COMPOUND

PROBLEM TO BE SOLVED: To provide a method for producing an aldoxime compound using no expensive catalysts and reagents and also requiring no severe reaction conditions. SOLUTION: There is provided a method for producing an aldoxime compound containing a process where an aldehyde compound and an oxime compound are brought into trans oximation reaction in the presence of perchloric acid and/or the metallic salt of perchloric acid in an organic solvent and water. The metallic salt of perchloric acid is preferably ferric perchlorate, cobalt perchlorate, nickel perchlorate, zinc perchlorate, aluminum perchlorate or calcium perchlorate. Also, the organic solvent is preferably methylene chloride and/or ethylene dichloride. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT

Br?nsted acid catalyzed transoximation reaction: Synthesis of aldoximes and ketoximes without use of hydroxylamine salts

The transoximation reaction enables the transfer of an oxime to a carbonyl compound and is catalyzed by transoximase in the pupae of the silkworm. Inspired by this bio-synthetic pathway, we achieved the transoximation of oximes to aldehydes and ketones catalyzed by a Br?nsted acid under mild conditions. Hydroxylamine salt, which necessitates a stoichiometric amount of base, was not required. NMR analysis clarified that this reaction proceeded through hydroxylamines generated by the successive hydrolysis of the oxime in situ. In addition, an environmentally benign method for catalytic transoximation was demonstrated in aqueous medium on a one hundred gram scale and the reaction filtrate containing the catalyst was recovered and reused over 10 times.

Electrochemical tandem synthesis of oximes from alcohols using KNO 3 as the nitrogen source, mediated by tin microspheres in aqueous medium

Electrochemical oximation of alcohols was realized with KNO3 as the nitrogen source mediated by tin microspheres.

NEW POLYMORPHIC FORMS OF N-[4-(TRIFLUOROMETHYL)BENZYL]-4-METHOXYBUTYRAMIDE

Crystalline polymorphic forms of a compound of formula N-[4-(trifluoromethyl)benzyl]-4-methoxybutyramide are described. The two polymorphic forms, named polymorphic Form A and polymorphic Form B, can be used in the treatment of drug addiction and alcoholism and have very good stability. Methods for preparing the polymorphic forms are also described.