74476-56-5

Upstream product

• 19112-35-7 ethyl (2-chlorobenzoyl)acetate 
• 609-65-4 o-chlorobenzoyl chloride 

Downstream Products

• 188679-29-0 Ethyl 4-(2-chlorophenyl)-2-(N-piperidino)-5-thiazolecarboxylate 
• 74476-58-7 ethyl 2-chloro-4-(o-chlorophenyl)-5-thiazolecarboxylate 
• 74476-57-6 ethyl 2-amino-4-(o-chlorophenyl)-5-thiazolecarboxylate 

Relevant academic research and scientific papers

Syntheses and Reactions of 2-Halo-5-thiazolecarboxylates

A variety of 2-halo-5-thiazolecarboxylates was prepared from substituted-3-aminoacrylates and 3-ketoesters.Selective reduction of 2-chloro-5-thiazolecarboxylates 4a, 4i and 4j with sodium borohydride in ethanol provided the corresponding 2-halo-5-thiazolemethanols 27 - 29.Nucleophilic displacement on methyl methanesulfonate (32c) occured selectivity at the 5-substituent to provide 2-chloro-4-(trifluoromethyl)-5-(heteroatom-substituted methyl)thiazoles 32d-f.

2-Amino-4-substituted-thiazolecarboxylic acids and their derivatives

2-Amino-4-substituted-5-thiazolecarboxylic acids and derivatives thereof, are intermediates for the preparation of 2-substituted-4-substituted-5-thiazolecarboxylic acid derivatives which are herbicidal safeners.