74491-36-4

Usage

Common uses

Antifungal medication for athlete's foot, ringworm, and vaginal yeast infections

Available forms

Cream, lotion, or solution for topical application

Mechanism of action

Inhibits the growth of fungus

Safety and tolerance

Generally considered safe and well-tolerated when used as directed.

Upstream product

• 4254-20-0 4,4'-dichlorobenzoin 
• 104-88-1 4-chlorobenzaldehyde 
• 203861-66-9 N-(4-chlorobenzylidene)methylamine N-oxide 
• 68240-86-8 4,5-bis(4-chlorophenyl)-1H-imidazole 
• 74-88-4 methyl iodide 

Downstream Products

• 489447-10-1 N-(piperidin-1-yl)-4,5-di-(4-chlorophenyl)-1-methylimidazole-2-carboxamide 
• 489447-14-5 4,5-di-(4-chlorophenyl)-1-methylimidazole-2-carboxylic acid 
• 489447-06-5 benzyl 4,5-di-(4-chlorophenyl)-1-methylimidazole-2-carboxylate 

Relevant academic research and scientific papers

Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists

Structure-activity relationship studies directed toward the optimization of 4,5-diarylimidazole-2-carboxamide analogs as human CB1 receptor inverse agonists resulted in the discovery of the two amide derivatives 24a and b (hCB1 IC50 = 6.1 and 4

Substituted imidazoles as cannabinoid receptor modulators

The use of compounds of the present invention as antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor particularly in the treatment, prevention and suppression of diseases mediated by the Cannabinoid-1 (CB1) receptor. The invention is concerned with the use of these novel compounds to selectively antagonize the Cannabinoid-1 (CB1) receptor. As such, compounds of the present invention are useful as psychotropic drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine. The compounds are also useful for the treatment of obesity or eating disorders associated with excessive food intake and complications associated therewith. Novel compounds of structural formula (I) are also claimed.

Studies in Heterocyclics: Novel Synthesis of 4,5-Diarylimidazoles

A novel synthesis of substituted 4,5-diarylimidazoles from N-(arylmethylene)methylamine N-oxides and cold aqueous ethanolic potassium cyanide is reported.A mechanism for the reaction is suggested.All the imidazoles have been screened for antibacterial, fu

The Reaction between Cyanide Ion and Nitrones; a Novel Imidazole Synthesis

By contrast with the CN-diphenylnitrones, cold aqueous ethanolic potassium cyanide converts N-methyl-C-phenylnitrone into 1-methyl-4,5-diphenylimidazole.The scope of this reaction has been investigated, and shown to proceed via intermediate cyano-imines, some of which have been synthesised by alternative routes.