74494-86-3Relevant academic research and scientific papers
A highly efficient nucleophilic substitution reaction between R2P(O)H and triarylmethanols to synthesize phosphorus-substituted triarylmethanes
Chen, Long,Fang, Xin-Yue,Zou, Yun-Xiang
supporting information, p. 951 - 956 (2018/02/19)
A highly efficient and general nucleophilic substitution reaction between dialkyl H-phosphonates or diarylphosphine oxides and triarylmethanols catalyzed by HOTf (trifluoromethanesulfonic acid) has been developed. It provides an atom-economical protocol for the synthesis of various symmetrical and unsymmetrical phosphorus-substituted triarylmethanes that constitute an emerging family of potent anticancer agents in rich diversity with 40 to 96% yields. The synthetic applicability of this protocol is demonstrated by gram-scale preparations.
The complex role of the triphenylmethyl motif in anticancer compounds
Palchaudhuri, Rahul,Nesterenko, Vitaliy,Hergenrother, Paul J.
supporting information; experimental part, p. 10274 - 10281 (2009/02/04)
Compounds incorporating the triphenylmethyl motif constitute an emerging family of potent anticancer agents. Although several small molecules containing this pharmacophore have now been identified, the mechanism of cell death induction for some of these c
PHOSPHOROUS CONTAINING COMPOUNDS INCLUDING TRIPHENYLMETHYLPHOSPHONATE ESTERS FOR THE TREATMENT OF MELANOMA AND OTHER CANCERS
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Page/Page column 2/4, (2008/06/13)
Compounds and related methods for synthesis, and the use of compounds and combination therapies for the treatment of cancer and modulation of apoptosis in cells are disclosed. Particularly disclosed are phosphonate esters. Compounds, methods of making the compounds, medicaments and method of manufacture of medicaments and therapeutic methods with applications against cancer including breast cancer, melanoma, colon cancer, leukemia and lymphoma, and other cancer cells are described.
Photolysis of triarylmethylphosphonic acids and their esters
Shi,Okamoto,Takamuku
, p. 453 - 460 (2007/10/02)
Upon UV-irradiation in an alkaline alcohol solution, some triarylmethylphosphonic acids underwent C-P bond cleavage to give triarylmethanes and alkyl dihydrogenphosphates, while, in an acidic or a neutral alcohol solution, they afforded biaryls. Their dimethyl esters gave also biaryls and dimethyl [alkoxy(aryl)methyl]phosphonates, which were derived from the insertion of (dialkoxyphosphinyl) arylcarbenes into the OH bond of the alcohol. The carbene was generated by photo-α,α-elimination of two aryl groups of the phosphonate.
