745033-60-7Relevant academic research and scientific papers
Synthesis of acetomycin bislactone analogues
Uenishi, Jun'ichi,Muraoka, Hironobu,Nameki, Masatake,Hata, Naoko
, p. 1343 - 1348 (2007/10/03)
Bislactones 5 and 6 have been designed as esterase-resistant acetomycin analogues and prepared in 10 steps from methyl 2-methylacetoacetate. Consecutive quaternary and tertiary carbon centers at the C-3 and C-4 positions on the γ-lactone ring are constructed by Pd-catalyzed allylic alkylation in one step. The relative stereochemistry for 6 has been determined by X-ray crystallographic analysis.
