74516-62-4

Basic information

• Product Name: VERRUCARIN A, A-ALLYLIC ALCOHOL OF
• CAS NO: 74516-62-4
• Molecular Formula: C₂₇H₃₄O₁₀
• Molecular Weight: 518.561
• Mol File: 74516-62-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 790.3°Cat760mmHg
• Flash Point: 264.5°C
• Density: 1.37g/cm³
• CAS DataBase Reference: VERRUCARIN A, A-ALLYLIC ALCOHOL OF(CAS DataBase Reference)
• NIST Chemistry Reference: VERRUCARIN A, A-ALLYLIC ALCOHOL OF(74516-62-4)
• EPA Substance Registry System: VERRUCARIN A, A-ALLYLIC ALCOHOL OF(74516-62-4)

Safety Data

• Hazardous Substances Data: 74516-62-4(Hazardous Substances Data)

Upstream product

• 74516-64-6 16-hydroxyverrucarin A 
• 3148-09-2 verrucarin A 
• 74526-04-8 16-oxoverrucarin A 

Downstream Products

• 74516-69-1 4β,8α,15-trihydroxy-12,13-epoxytrichothecene 

Relevant articles and documents

Antileukemic Compounds Derived from the Chemical Modification of Macrocyclic Trichothecenes. 1. Derivatives of Verrucarin A

Verrucarin A (2) was epoxidized to give the β-9,10-epoxide 7 (major product) and α-9,10-epoxide 9 (minor product).The β-epoxide 7 and its acetate 8 exhibit high in vivo antileukemic activity against P-388 mouse leukemia, whereas 2 and 9 are inactive.Epoxidation of verrucarin B (3) and roridin A (1) to their respective β-9,10-epoxides (11 and 12, respectively) also yields compounds with substantially increased activity.Allylic alcohols derived from 2, α-C8 (20), β-C8 (14), and C16 (15), were synthesized and tested; only 15 exhibited substantial in vivo activity.