7452-95-1

Usage

Uses

Used in Organic Synthesis:
4-(Trimethylsilyl)cyclohexanone is utilized as a building block in organic synthesis for its ability to contribute to the formation of complex molecular structures. Its presence in reactions can facilitate the synthesis of a wide range of organic compounds.
Used as a Precursor in Pharmaceutical and Agrochemical Industries:
In the pharmaceutical and agrochemical sectors, 4-(Trimethylsilyl)cyclohexanone serves as a precursor, enabling the development of new and effective drugs and pesticides. Its involvement in the synthesis process is crucial for creating molecules with desired therapeutic or pesticidal properties.
Used as a Protecting Group for Alcohols in Chemical Reactions:
4-(Trimethylsilyl)cyclohexanone is employed as a protecting group for alcohols during chemical reactions. This function is vital for preventing unwanted side reactions and ensuring the selective formation of desired products, thereby increasing the yield and purity of the target compounds.
Used as a Reactive Intermediate in Various Chemical Reactions:
4-(Trimethylsilyl)cyclohexanone also acts as a reactive intermediate in a multitude of chemical reactions. Its intermediate status allows for the transformation of other molecules or the formation of intermediates that are crucial for the synthesis of complex organic compounds.

Upstream product

• 195141-02-7 C₁₆H₂₀OSi 
• 6793-92-6 p-benzyloxyphenylbromide 
• 877-68-9 4-trimethylsilylanisole 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 13132-25-7 4-(trimethylsilyl)phenol 

Downstream Products

• 1138530-06-9 trimethyl(4-methylenecyclohexyl)silane 
• 7450-05-7 cis-4-(trimethylsilyl)cyclohexanol 
• 1621065-07-3 1-((4-methyl-2-((trans-4-(trimethylsilyl)cyclohexyl)oxy)naphthalen-1-yl)methyl)piperidine-4-carboxylic acid 
• 1621065-10-8 ethyl 1-((4-methyl-2-((cis-4-(trimethylsilyl)cyclohexyl)oxy)naphthalen-1-yl)methyl)piperidine-4-carboxylate 
• 1621065-09-5 1-((4-methyl-2-((cis-4-(trimethylsilyl)cyclohexyl)oxy)naphthalen-1-yl)methyl)piperidine-4-carboxylic acid 
• 1621065-08-4 ethyl 1-((4-methyl-2-((trans-4-(trimethylsilyl)cyclohexyl)oxy)naphthalen-1-yl)methyl)piperidine-4-carboxylate 
• 1544662-52-3 methyl 4-((6-(trans-4-(trimethylsilyl)cyclohexyloxy)naphthalen-2-yl)methylamino)bicyclo[2.2.2]octane-1-carboxylate 
• 1544662-48-7 cis-4-(trimethylsilyl)cyclohexyl methanesulfonate 
• 1544658-04-9 4-((6-(trans-4-(trimethylsilyl)cyclohexyloxy)naphthalen-2-yl)methylamino)bicyclo[2.2.2]octane-1-carboxylic acid 
• 910308-84-8 C₁₃H₁₈N₂SSi 
• 7452-94-0 (trans)-4-(trimethylsilyl)cyclohexanol 

Relevant academic research and scientific papers

Cobalt-Catalyzed Desymmetric Isomerization of Exocyclic Olefins

Chiral cyclic olefins, 1-methylcyclohexenes, are versatile building blocks for the synthesis of pharmaceuticals and natural products. Despite the prevalence of these structural motifs, the development of efficient synthetic methods remains an unmet challenge. Herein we report a novel desymmetric isomerization of exocyclic olefins using a series of newly designed chiral cobalt catalysts, which enables a straightforward construction of chiral 1-methylcyclohexenes with diversified functionalities. The synthetic utility of this methodology is highlighted by a concise and enantioselective synthesis of a natural product, β-bisabolene. The versatility of the reaction products is further demonstrated by multifarious derivatizations.

IMIDAZOPYRROLOPYRIDINE AS INHIBITORS OF THE JAK FAMILY OF KINASES

2-((1r,4r)-4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclohexyl)acetonitrile compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions mediated by JAK, such as inflammatory bowel disease.

S1P MODULATING AGENTS

Compounds of formula (I) can modulate the activity of one or more S 1P receptors. Sphingosine 1-phosphate (S IP) is a lysophospholipid mediator that evokes a variety of cellular responses by stimulation of five members of the endothelial cell differentiation gene (EDG) receptor family, namely S1P1, S1P2, S1P3, S1P4, and S1P5 (formerly EDG1, EDG5, EDG3, EDG6 and EDG8). The EDG receptors are G-protein coupled receptors (GPCRs) and on stimulation propagate second messenger signals via activation of heterotrimeric G-protein alpha (Ga.) subunits and beta-gamma (G()y) dimers.

COMPOUNDS THAT ARE S1P MODULATING AGENTS AND/OR ATX MODULATING AGENTS

Compounds of formula (I) can modulate the activity of one or more S1P receptors and/or the activity of autotaxin (ATX).

S1P MODULATING AGENTS

Compounds of formula (I) or (II) can modulate the activity of SIP receptors.

Diastereoselectivity control of the radical carboazidation of substituted methylenecyclohexanes

A systematic study of the diastereoselectivity of the radical carboazidation of methylenecyclohexane derivatives is presented. Several substitution patterns leading to a high level of stereocontrol have been identified. Axial attack is the preferred reaction pathway for cyclohexyl radicals, and excellent stereoselectivities can be obtained by introducing an axial substitutent at position 2. In this case, a second equatorial substituent at position 2 may be tolerated without a large detrimental effect on the diastereoselectivity. Finally, a high level of equatorial attack is observed with a very bulky substituent at position 2.

COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY

The present invention provides compounds of Formula (I) (wherein R1, R3, X, W, Z and ring Y are as defined herein). The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases or disorders associated with KSP kinesin activity and for inhibiting KSP kinesin activity.

Silicon and tin-directed Tiffeneau-Demjanov reaction

Silicon and tin substituents surprisingly have only a moderate directing effect on the Tiffeneau-Demjanov reaction. The low selectivity is rationalised as being due to the reactive nature of the diazonium ion leaving group, the weaker oxydiazene leaving g