74529-71-8

Basic information

• Product Name: 5-methyl-N-(4-methoxybenzoyl)oxazolidine-2,4-dione
• CAS NO: 74529-71-8
• Molecular Weight: 249.223
• Mol File: 74529-71-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-methyl-N-(4-methoxybenzoyl)oxazolidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-N-(4-methoxybenzoyl)oxazolidine-2,4-dione(74529-71-8)
• EPA Substance Registry System: 5-methyl-N-(4-methoxybenzoyl)oxazolidine-2,4-dione(74529-71-8)

Safety Data

• Hazardous Substances Data: 74529-71-8(Hazardous Substances Data)

Upstream product

• 27770-23-6 5-methyl-2,4-oxazolidinedione 
• 100-07-2 4-methoxy-benzoyl chloride 

Relevant articles and documents

N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases

The synthesis, inhibitory activity and mode of action of oxazolidine-2,4-diones against porcine pancreatic elastase, here used as a model for human neutrophil elastase, are reported. The nature of N-substitution at the oxazolidine-2,4-dione scaffold has large effect on the inhibitory potency against elastase. N-Acyl and N-sulfonyloxazolidine-2,4-diones emerged as potent pseudo-irreversible inhibitors, displaying high second-order rate constants for PPE inactivation. The title compounds were also shown to be potent inhibitors of human neutrophil elastase (HNE) and proteinase-3, and weak inhibitors of human cathepsin G. The results herein presented show that the oxazolidine-2,4-diones represent a new promising class of serine protease inhibitors.