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Benzenesulfonamide, 4-chloro-N-(2-chlorophenyl)-, also known as 4-chloro-N-(2-chlorophenyl)benzenesulfonamide, is a chemical compound with the molecular formula C12H9Cl2NO2S. It is a derivative of benzenesulfonamide, featuring a 4-chloro substituent and a 2-chlorophenyl group attached to the nitrogen atom. Benzenesulfonamide, 4-chloro-N-(2-chlorophenyl)- is primarily used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals, particularly in the production of herbicides and insecticides. Due to its chemical structure, it exhibits properties such as solubility in organic solvents and reactivity with nucleophiles, making it a valuable building block in organic synthesis.

7454-48-0

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7454-48-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 7454-48-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,4,5 and 4 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 7454-48:
(6*7)+(5*4)+(4*5)+(3*4)+(2*4)+(1*8)=110
110 % 10 = 0
So 7454-48-0 is a valid CAS Registry Number.

7454-48-0Relevant academic research and scientific papers

Natural Indian Natrolite zeolite-supported Cu nanoparticles: A new and reusable heterogeneous catalyst for N-arylation of sulfonamides with boronic acids in water under ligand-free conditions

Azarifar, Davood,Soleimanei, Fatemeh

, p. 12119 - 12126 (2014/03/21)

We report here on the preparation of primary sulfonamides and efficient, easily recoverable and reusable copper nanoparticles supported on natural Indian Natrolite zeolite as a catalyst for arylation of sulfonamides with arylboronic acids in water. The catalyst was characterized using the powder XRD, SEM, EDS and FT-IR spectroscopy. The significant advantages of this methodology are high yields, elimination of organic solvents, and simple work-up procedure. The catalyst was easily isolated from the reaction mixture and reused with no significant loss in its activity.

Fabrication, characterization and application of nanopolymer supported copper (II) complex as an effective and reusable catalyst for the CN bond cross-coupling reaction of sulfonamides with arylboronic acids in water under aerobic conditions

Nasrollahzadeh, Mahmoud,Rostami-Vartooni, Akbar,Ehsani, Ali,Moghadam, Majid

, p. 123 - 129 (2014/04/03)

This paper reports on the synthesis and use of nanopolymer supported copper (II) complex, as separable catalysts for N-arylation of sulfonamides with arylboronic acids in water. This method has the advantages of high yields, elimination of homogeneous cat

Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors

Fuwa, Haruhiko,Hiromoto, Kenichi,Takahashi, Yasuko,Yokoshima, Satoshi,Kan, Toshiyuki,Fukuyama, Tohru,Iwatsubo, Takeshi,Tomita, Taisuke,Natsugari, Hideaki

, p. 4184 - 4189 (2007/10/03)

Synthesis and biological evaluation of an arylsulfonamide class of γ-secretase inhibitors are described. Design, synthesis, and biological evaluation of multifunctional molecular probes harboring a benzophenone photophore as a cross-linking group and a biotin tag are also reported.

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