7454-65-1

Usage

Uses

Used in Pharmaceutical Research:
4-chloro-N-(2-methoxyphenyl)benzenesulfonamide is used as a pharmacological tool for studying the inhibition of carbonic anhydrase enzymes. Its ability to inhibit these enzymes has shown potential for therapeutic purposes, particularly in the treatment of neurological disorders, glaucoma, and certain types of cancer.
Used in Chemical Synthesis:
CMPSA, being a sulfonamide derivative, can be utilized in the synthesis of various organic compounds and pharmaceuticals. Its unique chemical structure allows for further modification and development of new compounds with potential applications in medicine and other industries.
It is important to handle CMPSA with caution, as it is a potentially hazardous chemical that can cause harm if not used properly.

Upstream product

• 90-04-0 2-methoxy-phenylamine 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 5720-06-9 2-Methoxyphenylboronic acid 
• 30066-82-1 N-chloro-p-chlorobenzenesulfonamide sodium salt 
• 98-64-6 4-Chlorobenzenesulfonamide 

Downstream Products

• 920011-90-1 N-{1-[2-(3-bromo-propoxy)-phenyl]-ethyl}-4-chloro-N-(2-methoxy-phenyl)-benzenesulfonamide 

Relevant academic research and scientific papers

Synthesis of N -Arylsulfonamides by a Copper-Catalyzed Reaction of Chloramine-T and Arylboronic Acids at Room Temperature

A copper-catalyzed Chan-Lam-coupling-like reaction of a (het)arylboronic acid and chloramine-T (or a related compound) has been developed for the synthesis of N -arylsulfonamides at room temperature in moderate to good yields, with good tolerance of functional groups. In this process, it is believed that chloramine-T serves as an electrophile.

Synthesis of N-(un)substituted-N-(2-methoxyphenyl/phenyl)-4-chlorobenzenesulfonamides as potent antibacterial derivatives

Sulfonamides belong to a biologically dynamic class of compounds with considerable importance for organic synthetic chemists. In the presented work, a benign series of chlorinated sulfonamides, 3a-b, was synthesized by coupling alkoxy (un) substituted ani

Synthesis, structural analysis and pharmacological screening of chlorinated sulfonamides

In present work, a facile and environmentally benign series of chlorinated sulfonamides was synthesized and screened against different enzymes. These were geared up by the coupling of 4-chlorobenzenesulfonyl chloride (1) with different substituted aromatic amines (2a-l) under dynamic pH control in aqueous media to form various chlorinated sulfonamides (3a-l). The synthesized chlorinated sulfonamides were spectrally characterized like 1H NMR, IR and EI-MS. The bioactivity of all the synthesized compounds were evaluated against urease, butyrylcholinesterase (BChE) and lipoxygenase (LOX) enzymes and found to be having talented activity against butyrylcholinesterase enzyme.

Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors

Synthesis and biological evaluation of an arylsulfonamide class of γ-secretase inhibitors are described. Design, synthesis, and biological evaluation of multifunctional molecular probes harboring a benzophenone photophore as a cross-linking group and a biotin tag are also reported.