7454-66-2Relevant academic research and scientific papers
Synthesis, antibacterial and lipoxygenase activities of N-[(dimethyl substituted)phenyl]-N-(4-chlorophenyl)-4-chlorobenzenesulfonamides
Aziz-Ur-Rehman,Ahmad, Imran,Abbasi, M. Athar,Nafeesa, Khadija,Siddiqui, Sabahat Z.,Hussain, Ghulam,Rahman, Jameel,Ahmed, Irshad,Afzal, Saira
, p. 1647 - 1650 (2015)
In present research work, a new series of N-[(dimethyl substituted)phenyl]-N-(4-chlorophenyl)-4-chlorobenzenesulfonamides (5a-f) was synthesized and also evaluated for their biological activities. The reaction of 4-chlorobenzenesulfonyl chloride (1) with dimethyl substituted aniline (2a-f) in aqueous alkaline medium yielded N-[(dimethyl substituted)phenyl]-4-chlorobenzenesulfonamides (3a-f). The target compounds 5a-f were synthesized by reacting the compounds 3a-f with electrophile, 4-chlorobenzyl chloride (4) in aprotic solvent, DMF and NaH. All the synthesized compounds were characterized by IR, 1H NMR and EIMS. All the synthesized derivatives were screened for antibacterial potential and were also subjected for lipoxygenase enzyme inhibition activity.
