74555-64-9Relevant academic research and scientific papers
Dianions of glyoxylic acid thioketals: convenient α-keto acid equivalents
Bates, Gordon S.,Ramaswamy, S.
, p. 716 - 722 (2007/10/02)
By varying the solvent, reaction temperature, and bases (i.e., gegenions present), optimum conditions for the alkylation of the dianions of glyoxylic acid derivatives 8 and 9 were established.It was found, that the easily prepared, thermally stable, tetrahydrofuran-soluble potassium dianion of bis(ethylthio)acetic acid was readily alkylated by alkyl halides, tosylates, epoxides, and N-tosyl aziridines.The latter alkylation is being used to develop a possible cytochalasin synthesis.The alkylated products may be readily converted into the corresponding α-keto acids or methyl 2,2-bismethoxycarboxylates.
