74563-01-2

Usage

Uses

Used in Pharmaceutical Industry:
Benzhydrol-d10 is used as an intermediate in the preparation of labeled Modafinil (M482500). Modafinil is a wakefulness-promoting agent used to treat conditions such as narcolepsy, sleep apnea, and shift work sleep disorder. The use of Benzhydrol-d10 in the synthesis of labeled Modafinil allows for the development of radiolabeled compounds, which can be used in research to study the pharmacokinetics, metabolism, and mechanism of action of Modafinil.
Used in Chemical Research:
Benzhydrol-d10 is also used in chemical research as a deuterated standard for various analytical techniques, such as nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The deuterium labeling in Benzhydrol-d10 provides a unique signature in these analytical methods, allowing for the accurate identification and quantification of the compound in complex mixtures.
Used in Synthesis of Deuterated Compounds:
Benzhydrol-d10 can be used as a starting material or building block in the synthesis of other deuterated compounds. The incorporation of deuterium atoms in organic molecules can provide valuable insights into the reaction mechanisms and improve the understanding of chemical processes. Additionally, deuterated compounds can exhibit altered physical and chemical properties compared to their non-deuterated counterparts, which can be useful in various applications, such as drug development and materials science.

Upstream product

• 22583-75-1 (2H₁₀)benzophenone 
• 1076-43-3 benzene-d6 
• 4165-57-5 bromobenzene-d5 
• 14132-51-5 2,3,4,5,6-pentadeuteriobenzaldehyde 

Downstream Products

• 80024-91-5 diphenylacetonitrile-d₁₀ 

Relevant academic research and scientific papers

Dual gold catalysis: Synthesis of polycyclic compounds via C-H insertion of gold vinylidenes

New and interesting polycyclic compounds have been synthesized from non-conjugated diyne systems by dual gold catalysis. A quaternary carbon center in the backbone and the accompanying Thorpe-Ingold effect enabled the unprecedented insertion of sp3 and sp2 C-H bonds that for the first time were incorporated within the backbone of the diyne system and allowed the construction of complex polycyclic carbon scaffolds inaccessible by previous approaches in which the C-H bonds for the insertion were situated at the other end of the alkyne.

Transformation of Carbinols by RuCl2(PPh3)3 and by Some Other Transition-Metal Catalysts

Several platinoid metal catalysts have been shown to promote reductive coupling, dehydration, disproportionation, and dehydrogenation of diarylcarbinols.Mechanistic studies were performed at 180-210 deg C with benzhydrol as substrate and RuCl2(PPh3)3 as catalyst.In aromatic hydrocarbon solvents the main process is reductive coupling.In this medium solvated RuCl2(PPh3)2 is suggested to be the active catalyst.In dimethyl sulfoxide the starting complex is transformed initially into RuCl2(PPh3)(Me2SO)2 and causes chiefly carbinol dehydrogenation.Ruthenium alkoxides are implied as common reaction intermediates in all four catalyses.Ruthenium hydrides are suggested to take part in the reductive coupling, disproportionation, and dehydrogenation processes.Some aliphatic and primary aromatic alcohols that do not react by themselves in the presence of RuCl2(PPh3)3 can both serve as active hydrogen donors and form crossover products in the presence of secondary and tertiary aromatic carbinols.