74563-32-9

Usage

Abbreviation

DPTBF

Molecular structure

Central tetrahydrobenzofuran ring with two phenyl groups attached at the 1 and 3 positions

Type of compound

Tetrahydrobenzofuran derivative

Pharmacological properties

a. Potential use as a ligand in the development of selective serotonin reuptake inhibitors (SSRIs)
b. Role in the modulation of the central nervous system

Other potential applications

a. Antimicrobial activity
b. Anti-inflammatory activity

Versatility

Exhibits potential for various pharmaceutical and research applications

Upstream product

• 7664-93-9 sulfuric acid 
• 104722-26-1 trans-1,2-dibenzoylcyclohexane 
• 64-19-7 acetic acid 
• 13225-62-2 1,8-diphenyl-1,7-octadiyne 
• 74563-17-0 C₂₀H₁₄O^(2-)*2Na⁽¹⁺⁾ 
• 5471-63-6 1,3-diphenylisobenzofuran 

Relevant academic research and scientific papers

Ruthenium-catalyzed transfer oxygenative cyclization of α,ω-diynes: Unprecedented [2 + 2 + 1] route to bicyclic furans via ruthenacyclopentatriene

A novel oxygen-atom-transfer process enables the catalytic [2 + 2 + 1] synthesis of bicyclic furans from α,ω-diynes with DMSO. [CpRu(AN)3]PF6 catalyzed the transfer oxygenative cyclization of diynes with aryl terminal groups, while t

Zinc-promoted reactions. 8. The effect of ring strain in the reduction of 1,2-dibenzoylcycloalkanes

Ring cleavage was the main route in the Zn reduction of 1 in neat AcOH, while selective carbonyl reduction predominated in the presence of LiCl. The less strained 2 underwent only carbonyl reduction with Zn/AcOH. The Clemmensen reduction of both 1 and 2 resulted mainly in acyclic products. The unstrained 3 was fairly resistant towards reduction, and did not undergo ring cleavage.

Reductive Metalation of 1,3-Diphenylisobenzofuran. Stereoselective Formation of Cis Products

1,3-Diphenylisobenzofuran was reduced in tetrahydrofuran by alkali metals to a dianion.This dianion on protonation, methylation, or carboxylation gave products which were predominantly cis.It is suggested that the dianion or the intermediate monoreacted monoanion adopts a preferred conformation in which steric interaction between the phenyl substituents is minimized and orbital overlap between the carbanion and the benzene ring is maximized.By use of this stereoselectivity of the dianion, a series of 1,3-polymethylene-bridged 1,3-diphenylphthalans was prepared.The possibility of single electron transfer during the alkylation of the dianion was examined by alkylating the dianion with tert-butyl halides.Complex reaction mixtures were formed but extensive alkylation occurred and mono- and dialkylation products were characterized.