7457-09-2Relevant academic research and scientific papers
Regio- And stereoselective intermolecular hydroalkoxylation of alkynes catalysed by cationic gold(I) complexes
Corma, Avelino,Ruiz, Violeta R.,Leyva-Perez, Antonio,Sabater, Maria J.
scheme or table, p. 1701 - 1710 (2010/10/04)
Vinyl ethers and ketals are obtained from the reaction of phenylacetylene derivatives and dimethyl acetylenedicarboxylate (DMAD) with alcohols in good yields and levels of stereoselectivity by using cationic gold(I)-phosphine complexes as catalysts. By choosing the appropriate phosphine, the selective formation of the Z or the E isomer of the vinyl ether can be tuned, and the undesired formation of the ketal can be controlled. The isomerisation of fumarates (Z-isomer) to maleates (E-isomer) is a gold-catalysed process that can be conducted in onepot. When using polyols, 5-membered cyclic ketals are easily isolated by extraction with hexane and the gold complex can be reused.
