74590-69-5

Upstream product

• 6212-33-5 2-(4-Chlorophenyl)glycine 
• 1878-66-6 4-chlorophenylacetic Acid 
• 75581-01-0 4-(4-chlorobenzylidene)-2,2,6,6-tetramethyl-3,5-dioxa-2,6-disilaheptane 
• 373-91-1 hypofluorous acid trifluoromethyl ester 

Downstream Products

• 492-86-4 (R)-4-chloro-α-hydroxy-benzeneacetic acid 
• 171334-87-5 (R)-(4-Chloro-phenyl)-fluoro-acetic acid (S)-1-(4-nitro-phenyl)-ethyl ester 
• 171334-86-4 (R)-(4-Chloro-phenyl)-fluoro-acetic acid (S)-1-(4-methoxy-phenyl)-ethyl ester 
• 171334-35-3 (R)-(4-Chloro-phenyl)-fluoro-acetic acid (S)-2-methyl-1-phenyl-propyl ester 
• 171334-34-2 (R)-(4-Chloro-phenyl)-fluoro-acetic acid (R)-2-methyl-1-phenyl-propyl ester 
• 171334-31-9 (R)-(4-Chloro-phenyl)-fluoro-acetic acid (S)-1-phenyl-ethyl ester 
• 171334-30-8 (R)-(4-Chloro-phenyl)-fluoro-acetic acid (R)-1-phenyl-ethyl ester 

Relevant academic research and scientific papers

Configuration d'esters derives d'acides 2-fluoro-2-phenylacetique phenyles substitues, par RMN du fluor

The 19 F NMR chemical shifts (δF) of the p-ZPhCHFCO2CHL1L2 esters of 2-fluoro-2-substituted aryl acetic acids have been measured.The δF values of the two diastereoisomers of these esters are linearly related to the ?+ Brown-Okamoto substituent parameters for each term of the series studied.The configuration of such esters of arylacetic acid can be deduced from their δF values when compared to those of esters derived from the non-substituted acid of known configuration.

Synthesis of α-fluorocarbonyl compounds

Process for preparing an organic compound of the formula R2 R2 CFC(O)R3, which process comprises contacting and reacting in a reaction mixture which includes an inert solvent, at a temperature of -40° C. to -100° C., ROF and STR1 R is polyfluoroperhaloalkyl of 1-6 carbon atoms or FOCF2 ; R1 is hydrocarbyl of 1-6 carbon atoms; each R2 is selected from H, alkyl of 1-17 carbon atoms, cycloalkyl of 3-6 carbon atoms, aryl, heteroaryl and such alkyl, cycloalkyl, aryl and heteroaryl substituted by halogen or alkoxy of 1-6 carbon atoms; R3 is selected from H, alkyl and haloalkyl of 1-16 carbon atoms, cycloalkyl of 3-10 carbon atoms, aryl and haloaryl, OSi(R1)3, OH, NH2, alkoxy of 1-6 carbon atoms, aryloxy, NHR1 and NR12 wherein R1 is alkyl of 1-6 carbon atoms, N-arylamino and nitrogen or sulfur heterocyclic of 4-5 carbon atoms; R3 and one R2 taken together is a diradical which with the C=C group is carbocyclic, heterocyclic or haloheterocyclic, and recovering from the reaction mixture the compound of the formula R2 R2 CFC(O)R3.