74592-82-8Relevant academic research and scientific papers
Synthesis of 1- and 4-substituted piperazin-2-ones via Jocic-type reactions with N-substituted diamines
Perryman, Michael S.,Earl, Matthew W. M.,Greatorex, Sam,Clarkson, Guy J.,Fox, David J.
supporting information, p. 2360 - 2365 (2015/03/04)
Enantiomerically-enriched trichloromethyl-containing alcohols, obtained by asymmetric reduction, can be transformed regioselectively into 1-substituted piperazinones by modified Jocic reactions with little or no loss of stereochemical integrity. This meth
Reeve's synthesis of 2-imino-4-thiazolidinone from alkyl (aryl) trichloromethylcarbinol revisited, a three-component process from aldehyde, chloroform and thiourea
Blanchet, Jér?me,Zhu, Jieping
, p. 4449 - 4452 (2007/10/03)
An efficient synthesis of 2-imino-4-thiazolidinones from readily accessible alkyl (aryl) trichloromethylcarbinols and thioureas under mild conditions is reported. A one-pot three-component synthesis of the title compounds from aldehyde, chloroform and thiourea is also developed for the first time
