82772-38-1

Basic information

• Product Name: α-(trichloromethyl)benzenepropanol
• Synonyms: α-(trichloromethyl)benzenepropanol
• CAS NO: 82772-38-1
• Molecular Weight: 253.556
• Mol File: 82772-38-1.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: α-(trichloromethyl)benzenepropanol(CAS DataBase Reference)
• NIST Chemistry Reference: α-(trichloromethyl)benzenepropanol(82772-38-1)
• EPA Substance Registry System: α-(trichloromethyl)benzenepropanol(82772-38-1)

Safety Data

• Hazardous Substances Data: 82772-38-1(Hazardous Substances Data)

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 650-51-1 sodium trichloroacetate 
• 76-03-9 trichloroacetic acid 
• 67-66-3 chloroform 
• 122-97-4 3-Phenyl-1-propanol 
• 74592-82-8 1,1,1-trichloro-3-phenylpropan-2-ol 
• 1592-38-7 2-Naphthalenemethanol 
• 358720-84-0 trimethyl(1,1,1-trichloro-4-phenylbutan-2-yloxy)silane 
• 96349-58-5 (E)-1,1,1-trichloro-4-phenylbut-3-en-2-ol 
• 56-23-5 tetrachloromethane 

Downstream Products

• 85363-88-8 α-(dichloromethyl)benzenepropanol 
• 139040-36-1 4-phenyl-1,1,1-trichloro-2-butanone 
• 263904-20-7 α-(trichloromethyl)benzenepropanol 4-methylbenzenesulfonate 
• 16520-62-0 4-Phenyl-1-butyne 
• 2550-26-7 4-Phenyl-2-butanone 
• 62692-42-6 (Z)-1-chloro-4-phenyl-1-butene 
• 20845-80-1 1-chloro-4-phenylbutan-2-one 
• 1050443-42-9 4-Phenyl-2-deuterobutyric acid 
• 1821-12-1 4-Phenylbutyric acid 

Relevant articles and documents

Application of piperazine structure containing compound to preparation of LSD1 (Lysine Specific Demethylase 1) inhibitor

The invention discloses application of a piperazine structure containing compound to the preparation of a histone lysine specific demethylase (LSD1) inhibitor. The structural general formula of the compound is as shown in the following descriptions (wherein, A is hydrogen, carbonyl or thiocarbonyl) or a configurational isomer and a pharmaceutical salt thereof, or is as shown in the following descriptions or a pharmaceutical salt thereof. The compound has an obvious inhibition effect on the LSD1, can be prepared into the LSD1 inhibitor, and is used for preventing and treating a disease related to the activity of the histone LSD1.

Synthesis of 1- and 4-substituted piperazin-2-ones via Jocic-type reactions with N-substituted diamines

Enantiomerically-enriched trichloromethyl-containing alcohols, obtained by asymmetric reduction, can be transformed regioselectively into 1-substituted piperazinones by modified Jocic reactions with little or no loss of stereochemical integrity. This meth

One-pot in situ formation and reaction of trimethyl(trichloromethyl)silane: Application to the synthesis of 2,2,2-trichloromethylcarbinols

2,2,2-Trichloromethylcarbinols are 1 are valuable synthetic intermediates with a multitude of uses. A scalable procedure for the synthesis of TMS-protected-2,2,2-trichloromethylcarbinols and 2,2,2-trichloromethylcarbinols 1 was developed that employs the in situ generation and reaction of trimethyl(trichloromethyl)silane (CCl3-TMS). The procedure avoids the exposure of the carbonyl compounds to the strongly basic conditions typically used for this transformation and also avoids isolation of the difficult-to-handle CCl3-TMS. This procedure was applied to diastereoselective trichloromethyl additions to 2-substituted 4-piperidinones and to reactions with a variety of structurally diverse aldehydes and ketones.