74605-12-2

Usage

Uses

Used in Medicinal Chemistry:
4-(2,5-DIMETHOXY-PHENYL)-THIAZOL-2-YLAMINE is used as a pharmaceutical precursor for the development of drugs targeting various diseases. Its unique structure and functional groups contribute to its potential therapeutic properties, making it a valuable compound in the discovery and synthesis of novel medicinal agents.
Used in Scientific Research:
In the realm of scientific research, 4-(2,5-DIMETHOXY-PHENYL)-THIAZOL-2-YLAMINE serves as a reagent or building block in organic synthesis. Its versatile chemical properties allow for the creation of new compounds with potential applications in various fields, including materials science, pharmaceuticals, and agrochemicals.
Used in Antifungal Applications:
4-(2,5-DIMETHOXY-PHENYL)-THIAZOL-2-YLAMINE is used as an antifungal agent in the agricultural and medical industries. Its structural features and functional groups may provide effective protection against fungal infections, making it a promising candidate for the development of new antifungal products.
Used in Antibacterial Applications:
In the field of antibacterial research, 4-(2,5-DIMETHOXY-PHENYL)-THIAZOL-2-YLAMINE is being studied for its potential as an antibacterial agent. Its unique chemical properties may offer a new approach to combating bacterial infections, particularly those resistant to conventional antibiotics.
Used in Drug Discovery:
4-(2,5-DIMETHOXY-PHENYL)-THIAZOL-2-YLAMINE is used as a lead compound in drug discovery, where its biological activity is being investigated for potential therapeutic applications. Its presence in various screening assays and medicinal chemistry studies highlights its importance in the search for new drugs to treat a wide range of diseases.

InChI:InChI=1/C11H12N2O2S/c1-14-7-3-4-10(15-2)8(5-7)9-6-16-11(12)13-9/h3-6H,1-2H3,(H2,12,13)

Upstream product

• 1201-38-3 2',5'-dimethoxyacetophenone 
• 17356-08-0 thiourea 
• 1204-21-3 2-bromo-2',5'-dimethoxyacetophenone 

Downstream Products

• 81529-85-3 2-Ethoxyethyl N-[4-(2,5-dimethoxyphenyl)-thiazol-2-yl]-oxamate 
• 91402-18-5 N-[4-(2,5-Dimethoxy-phenyl)-thiazol-2-yl]-2-piperidin-1-yl-acetamide 
• 91402-15-2 2-(N-Isobutylaminoacetamido)-4-(2',5'-dimethoxy)phenylthiazole 
• 91402-16-3 2-sec-Butylamino-N-[4-(2,5-dimethoxy-phenyl)-thiazol-2-yl]-acetamide 
• 91402-17-4 2-Diethylamino-N-[4-(2,5-dimethoxy-phenyl)-thiazol-2-yl]-acetamide 
• 91402-14-1 N-[4-(2,5-Dimethoxy-phenyl)-thiazol-2-yl]-2-isopropylamino-acetamide 
• 91402-13-0 N-[4-(2,5-Dimethoxy-phenyl)-thiazol-2-yl]-2-ethylamino-acetamide 
• 112434-74-9 4-(2,5-Dimethoxy-phenyl)-5-(2,2-dimethyl-chroman-6-ylazo)-thiazol-2-ylamine 

Relevant academic research and scientific papers

Aiding the versatility of simple ammonium ionic liquids by the synthesis of bioactive 1,2,3,4-tetrahydropyrimidine, 2-aminothiazole and quinazolinone derivatives

Simple ammonium ionic liquids [ILs] are efficient, green, environmentally friendly catalysts in promoting the Biginelli condensation reaction, Hantzsch reaction and Niementowski reaction to afford 1,2,3,4-tetrahydropyrimidine, 2-aminothiazole and quinazolinone derivatives respectively by eliminating the need for harmful volatile organic solvents. These [ILs] are air and water stable, easy to prepare and cost-effective. The effects of the anions and cations present in [IL] on reactions were investigated. The results clearly indicated that the Biginelli condensation reaction, Hantzsch reaction and Niementowski reaction were heavily influenced by the acidity of [IL], and among various ammonium ionic liquids, [Et3NH][HSO4] showed the best catalytic activity. Furthermore, [IL] could be easily separated and reused with a slight loss of its activity. This technique provided a good alternative way for the industrial synthesis of 1,2,3,4-tetrahydropyrimidinones, 2-aminothiazoles and quinazolinones. The present processes are eco-friendly methods for the synthesis of these derivatives authenticated by several green parameters, namely,E-factor, process mass intensity, reaction mass efficiency, atom economy, and carbon efficiency.

Five-membered heterocyclic compounds as inhibitors of SRC family protein kinase.

The present invention refers to novel substituted aromatic heteroaryl derivatives of formula (I). with the definitions of A, L1, L2, G, J, X and Y according to claim 1. These novel compounds are useful for the inhibition of protein kinases, particularly of the inhibition of Src family protein kinases. Methods for inhibiting kinases by contacting kinases with these novel compounds are disclosed. In another embodiment the present invention refers to pharmaceutical compositions containing these novel compounds and their use for the preparation of medicaments for treating diseases or disorders associated with unphysiological activity of kinases in the body, particularly for the treatment of cancer, immunosuppression, and osteoporosis.

Synthesis and complexing properties of 4-arylthiazolyl-substituted Schiff bases

Reactions of 2-amino-4-arylthiazoles with aromatic aldehydes afforded the corresponding Schiff bases. Complex formation of the latter with nickel, zinc, cobalt, manganese, and copper salts was studied.

Intramolecular weak hydrogen bonds in substituted 4-arylthiazoles

We have synthesized new polysubstituted 4-arylthiazoles with a substitution pattern able to form intramolecular weak hydrogen bonds as secondary structure, and besides, displaying in the aromatic region of their 1H-NMR spectra an ABX spin system and only one singlet (the thiazolic proton), thus permitting us to make doubtless assignments. These results confirmed previous assignments made by us in other thiazole-derivatives prepared by the first time. The spectroscopic data (IR, 1H-NMR and MS) of these thiazoles, as well as of the required intermediates, are discussed.

Synthesis and Antimicrobial Activity of Some 2-Amino-4-aryl-5-chromanylazothiazoles

The title compounds have been synthesised by the condensation of diazotised 6-amino-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran with different 2-amino-4-arylthiazoles which in turn have been prepared by cyclocondensation of acetophenones with thiourea in the