74609-51-1

Basic information

• Product Name: (trans-4a,8a)-octahydro-2H-1,4-benzoxazine
• Synonyms: (trans-4a,8a)-octahydro-2H-1,4-benzoxazine
• CAS NO: 74609-51-1
• Molecular Weight: 141.213
• Mol File: 74609-51-1.mol

Chemical Properties

• CAS DataBase Reference: (trans-4a,8a)-octahydro-2H-1,4-benzoxazine(CAS DataBase Reference)
• NIST Chemistry Reference: (trans-4a,8a)-octahydro-2H-1,4-benzoxazine(74609-51-1)
• EPA Substance Registry System: (trans-4a,8a)-octahydro-2H-1,4-benzoxazine(74609-51-1)

Safety Data

• Hazardous Substances Data: 74609-51-1(Hazardous Substances Data)

Upstream product

• 85515-95-3 trans-RS-N-(β-hydroxyethyl)-2-amino-1-cyclohexanol 
• 74572-17-1 trans-RS-N-p-toluensulphonyl-octahydro-1,4-benzoxazine 
• 142034-77-3 (trans-4a,8a)-hexahydro-2H-1,4-benzoxazin-3(4H)-one 
• 931-15-7 (1R,2R)-2-aminocyclohexanol 
• 142034-76-2 2-chloro-N-[trans-(1,2)-2-hydroxycyclohexyl]acetamide 
• 74572-18-2 Toluene-4-sulfonic acid 2-[(2-hydroxy-cyclohexyl)-(toluene-4-sulfonyl)-amino]-ethyl ester 
• 286-20-4 cyclohexane-1,2-epoxide 

Relevant articles and documents

CYCLIC AMIDE DERIVATIVES AS INHIBITORS OF 11 - BETA - HYDROXYSTEROID DEHYDROGENASE AND USES THEREOF

The present invention relates to certain amide derivatives that have the ability to inhibit 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and which are therefore useful in the treatment of certain disorders that can be prevented or treated by inhibition of this enzyme. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders. It is expected that the compounds of the invention will find application in the treatment of conditions such as non-insulin dependent type 2 diabetes mellitus (NIDDM), insulin resistance, obesity, impaired fasting glucose, impaired glucose tolerance, lipid disorders such as dyslipidemia, hypertension and as well as other diseases and conditions.

SYNTHESIS AND ABSOLUTE CONFIGURATION OF SUBSTITUTED MORPHOLINES

We studied methods of stereospecific synthesis that enabled us to obtain variously substituted morpholinic compounds and to determine their absolute configuration.From a study of the chiroptical properties of synthetic N-(2-pyridyl-N-oxide) derivatives of optically active morpholines, it was possible to correlate the sign of the Cotton effect with the absolute configuration.This correlation agrees with that previously established for derivatives of the piperidine type.By evaluating the various contributions to the Cotton effect of substituents in positions 2 and 3, we established the absolute configuration of bicyclic compounds condensed in the two positions mentioned above.