7461-51-0

Basic information

• Product Name: 2,4,6-Trinitrobenzoinoic acid anylide
• Synonyms: 2,4,6-Trinitrobenzoinoic acid anylide;3,5-Dinitrobenzanilide;Benzamide, 3,5-dinitro-N-phenyl-;Nsc403513;3,5-Dinitro-N-phenylbenzaMide, 97%
• CAS NO: 7461-51-0
• Molecular Formula: C₁₃H₉N₃O₅
• Molecular Weight: 287.22766
• Mol File: 7461-51-0.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 382.6°Cat760mmHg
• Flash Point: 185.2°C
• Appearance: /
• Density: 1.496g/cm³
• Vapor Pressure: 4.67E-06mmHg at 25°C
• Refractive Index: 1.696
• CAS DataBase Reference: 2,4,6-Trinitrobenzoinoic acid anylide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-Trinitrobenzoinoic acid anylide(7461-51-0)
• EPA Substance Registry System: 2,4,6-Trinitrobenzoinoic acid anylide(7461-51-0)

Safety Data

• Hazardous Substances Data: 7461-51-0(Hazardous Substances Data)

Usage

General Description

2,4,6-Trinitrobenzoinoic acid anylide is a chemical compound that is commonly used in the manufacturing of explosives and propellants. It is a yellow crystalline solid that is highly reactive and sensitive to heat, friction, and impact. The compound can undergo explosive decomposition when exposed to certain conditions, making it a hazardous material to handle. Due to its explosive nature, 2,4,6-Trinitrobenzoinoic acid anylide is strictly regulated and its use is closely monitored. It is important to exercise caution and follow proper safety procedures when working with or handling this compound to prevent accidents and ensure the safety of personnel and facilities.

InChI:InChI=1/C13H9N3O5/c17-13(14-10-4-2-1-3-5-10)9-6-11(15(18)19)8-12(7-9)16(20)21/h1-8H,(H,14,17)

Upstream product

• 42444-51-9 3,5-dinitrobenzoyl azide 
• 62-53-3 aniline 
• 99-33-2 3,5-dinitrobenoyl chloride 
• 99-34-3 3,5-dinitrobenzoic acid 
• 6244-76-4 3,5-Dinitro-N-phenyl-thiobenzamide 
• 65-85-0 benzoic acid 
• 105673-76-5 3,5-Dinitro-N-phenyl-benzimidic acid 4-nitro-phenyl ester 
• 29955-47-3 3,5-Dinitro-N-phenyl-benzimidoyl chloride 

Downstream Products

• 73454-97-4 3,5-dinitro-N-(2,4-dinitrophenyl)benzamide 

Relevant articles and documents

A new mechanism for selective recognition of cyanide in organic and aqueous solution

A simple colorimetric and fluorimetric chemosensor 3,5-dinitro-(N-phenyl)benzamide (DNBA), was synthesized for selective determination of cyanide anion in organic and aqueous solutions via novel chemodosimeter approach. The chemosensor DNBA showed a chrom

Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum

Quinoline antimalarials target hemozoin formation causing a cytotoxic accumulation of ferriprotoporphyrin IX (Fe(III)PPIX). Well-developed SAR models exist for β-hematin inhibition, parasite activity, and cellular mechanisms for this compound class, but no comparably detailed investigations exist for other hemozoin inhibiting chemotypes. Here, benzamide analogues based on previous HTS hits have been purchased or synthesized. Only derivatives containing an electron deficient aromatic ring and capable of adopting flat conformations, optimal for π-π interactions with Fe(III)PPIX, inhibited β-hematin formation. The two most potent analogues showed nanomolar parasite activity, with little CQ cross-resistance, low cytotoxicity, and high in vitro microsomal stability. Selected analogues inhibited hemozoin formation in Plasmodium falciparum causing high levels of free heme. In contrast to quinolines, introduction of amine side chains did not lead to benzamide accumulation in the parasite. These data reveal complex relationships between heme binding, free heme levels, cellular accumulation, and in vitro activity of potential novel antimalarials.

Selective colorimetric sensing of anions in aqueous media through reversible covalent bonding

(Chemical Equation Presented) Selective colorimetric sensing of anions in aqueous media has been studied, which involves reversible covalent bonding as key binding interactions. By introducing a simple nitro chromophore into an o-(carboxamido)trifluoroace