7461-77-0Relevant academic research and scientific papers
A study concerning the synthesis, basicity and hydrolysis of 4-amino-2-(n,n-diethylamino)quinazoline derivatives
Zielinski, Wojciech,Kudelko, Agnieszka
, p. 1289 - 1292 (2007/10/03)
A group of 2-(N,N-diethylamino)-4-aminoquinazoline derivatives have been synthesized in the reaction of N1,N1-diethyl-N2-arylchlorocarboxyamidines with cyanamide in the presence of TiCl4 as a catalyst. Such quin
Isoquinoline and quinazoline urea analogues as antagonists for the human-adenosine A3 receptor
Van Muijlwijk-Koezen, Jacqueline E.,Timmerman, Henk,Van Der Goot, Henk,Menge, Wiro M. P. B.,Von Drabbe Künzel, Jacobien Frijtag,De Groote, Miriam,Ijzerman, Adriaan P.
, p. 2227 - 2238 (2007/10/03)
Isoquinoline and quinazoline urea derivatives were found to bind to human adenosine AS receptors. Series of N-phenyl-N'-quinazolin-4-ylurea derivatives and N-phenyl-N'-isoquinolin-1-ylurea derivatives were synthesized and tested in radioligand binding ass
4-Amino-pyrimidine derivatives
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, (2008/06/13)
A process is described for the preparation of pyrimidine derivatives having therapeutic properties. They have the general formula: SPC1 Wherein A represents an alkylene or alkenylene grouping which together with the carbon atoms of the pyrimidine nucleus to which it is attached forms a homocyclic ring containing five to seven carbon atoms, which homocyclic ring may carry one or more halogen, lower alkyl and/or lower alkoxy substituents and R represents an amino, lower alkylamino or di(lower)alkylamino group, or a nitrogen-, oxygen- or sulphur-containing saturated or unsaturated mononuclear heterocyclic group linked to the pyrimidine ring either through a carbon atom or, when the group contains a nitrogen atom, either through the nitrogen atom or a carbon atom and are prepared by reacting a cycloaliphatic(A)oaminonitrile with a nitrile of the formula R-CN where A and R have the above meanings in the presence of a basic alkali metal-containing compound and then reacting the resultant intermediate with water. The compounds have heretofore undiscovered antimicrobial and antihypertensive properties.
